诱导痰中肿瘤标志物水平在不同分型肺癌早期诊断中的意义  

Levels of tumor markers in induced sputum in different classification of lung cancer and its significance for early diagnosis

作　　者：李伟棠[1] 钟英豪[1] 黄兰卿[1] 胡浩[1] 

机构地区：[1]广东省江门市人民医院呼吸内科,广东江门529020

出　　处：《中国现代医生》2015年第6期3-5,共3页China Modern Doctor

基　　金：广东省江门市第二批科技计划项目

摘　　要：目的观察不同病理类型肺癌患者诱导痰中肿瘤标志物癌胚抗原(CEA)、神经元特异性烯化醇(NSE)、细胞角蛋白19片段(CYFRA21-1)水平及其对早期诊断的敏感性和特异性。方法 86例经病理检查确诊为不同类型肺癌患者,与101例健康对照组进行对比研究,分别检测患者诱导痰中CEA、NSE、CYFRA21-1水平并进行统计学分析。结果肺癌组CEA、NSE、CYFRA21-1水平均较健康对照组高,其中CEA在腺癌中增高明显,NSE在小细胞肺癌中增高明显,而CYFRA21-1在鳞癌中较其他组高。三项指标联合检测可将敏感性提高到74.4%,特异性为86.1%。结论诱导痰操作灵便、创伤少且可控性强,在早期诊断中敏感性和特异性较高,CEA、NSE、CYFRA21-1的联合检测宜推广于临床。Objective To observe different pathological type of tumor markers in patients with lung cancer induced sputum carcinoembryonic antigen（CEA）, neuron specific alkylene glycol（NSE） and cytokeratin 19 fragment （CYFRA21- 1 ） level and its sensitivity and specificity for early diagnosis. Methods All 86 patients confirmed by pathological examination for different types of lung cancer patients and 101 cases of healthy controls were detected CEA, NSE, CYFRA21-1 levels in induced sputum and analyzed statistically. Results In lung cancer group CEA, NSE, CYFRA21- 1 levels were higher than healthy controls, the CEA in adenocarcinoma patients increased significantly, NSE in small cell lung cancer increased significantly and CYFRA21-1 in squamous cell carcinomas was higher than other groups. Three parallel joint detection may increase the sensitivity to 74.4%, specificity to 86.1%. Conclusion Induced sputum with facility operation, less trauma, controllability is strong, and has high sensitivity and specificity in the early diagnosis, CEA, NSE, CYFRA21-1 joint detection should be promoted in clinical.

关 键 词：诱导痰 癌胚抗原 神经元特异性烯化醇 细胞角蛋白19片段 

分 类 号：R734.2[医药卫生—肿瘤]