清音丸改剂型前后抗炎镇痛作用比较  

Comparison study of anti-inflammatory and analgesic effects of Qingyin pills and Qingyin tablet

作　　者：李雪梅[1,2] 周建平[2] 孙建宁[1] 

机构地区：[1]北京中医药大学中药学院,100102 [2]北京市药品检验所药理室,100035

出　　处：《武警医学》2015年第2期136-138,141,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的对比分析清音丸由蜜丸改成片剂后的抗炎、镇痛作用。方法采用ICR小鼠,SD大鼠,随机分为空白对照组,清喉利咽颗粒组,布洛芬组,清音丸、片高、中、低剂量组(按生药量计,0.910,0.455,0.228 g/kg),1次/d,连续给药10 d。比较清音丸、片两个不同剂型对小鼠毛细血管通透性急性渗出性炎性反应、大鼠棉球肉芽肿炎性增殖抑制及腹腔注射醋酸致小鼠扭体的镇痛作用。结果与空白对照组相比,清音片、清音丸各剂量组小鼠腹腔渗出液的吸光度值明显减少,差异具有统计学意义(P<0.01)。清音丸抑制作用更强;清音丸、片各剂量组对肉芽的增生有明显的抑制作用,与空白对照组比较差异有统计学意义(P<0.01)。清音片各剂量组对肉芽肿组织生长抑制率数值分别为56.80%、47.14%、54.18%,明显高于清音丸各剂量组抑制率数值;清音丸、片两种剂型各剂量组的镇痛百分率都达到了50%,且清音丸各剂量组的镇痛百分率分别为64.52%、64.52%、48.60%,其镇痛作用效果强于清音片。结论清音丸由蜜丸剂型改为片剂后仍具有抗炎、镇痛作用。Objective Comparison of two different dosage of anti-inflammatory and analgesic effects of Qingyin honey pills and Qingyin tablets. Methods ICR mice and SD rats were divided into blank control group,Qinghou Liyan granules group and ibuprofen group at random. The high-dose,the middle-dose and the low-dose groups of qingyin pills were treated by gavage for 10 d（ according to the crude drug,0. 910,0. 455,0. 228 g / kg）. Comparison of analgesic effect of two different dosage-honey pills and tablets on the capillary permeability in mice with acute exudative inflammation,rat granuloma inflammatory proliferation inhibition and acetic acid writhing test. Results All groups of Qingyin pills and tablets showed that optical density of peritoneal exudates in mice were be significantly reduced. There was significant differences in optical density,compared with the control group（ P 0. 01）. In Qingyin pills groups,inhibitory effects on the capillary permeability in mouse abdominal cavity with acute exudative inflammation was stronger. All groups of Qingyin pills and tablets showed some inhibitory effects on granuloma inflammatory proliferation. There was significant differences in inhibition rate,compared with blank control group（ P 0. 01）. The inhibition rates were 56. 80%,47. 14%,and 54. 18%,respectively,in all groups of Qingyin pills. The inhibition rate of Qingyin tablets was higher than those of Qingyin pills groups. Both groups of Qingyin tablets＇ analgesic effect ratios were higher than 50%,analgesia percentages of Qingyin pills were 64. 52%,64. 52%,and 48. 60%,respectively. Analgesic effect of Qingyin pills was stronger than analgesic effect of Qingyin tablets. Conclusions Qingyin pills and tablets show anti-inflammatory and analgesic effects,and Qingyin pills and tablets show their respective advantages in different inflammatory types. Qingyin pills still maintain the anti-inflammatory and analgesic effects as original pills after change in dose form.

关 键 词：清音丸 清音片 改剂型 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]