骨肉瘤转移侵袭机制研究进展  

Research progress on the mechanism of metastasis and invasion of osteosarcoma

作　　者：胡涂[1] 杨庆诚[1] 程冬冬[1] 

机构地区：[1]上海交通大学附属第六人民医院骨科,200023

出　　处：《中国骨与关节杂志》2015年第1期41-44,共4页Chinese Journal of Bone and Joint

摘　　要：骨肉瘤是儿童和青少年最常见的原发性恶性骨肿瘤[1-2]。在20世纪70年代以前，单纯手术切除治疗方案骨肉瘤的生存率只有15%～20%，如今手术联合新辅助化疗治疗方案使骨肉瘤的生存率提高到近80%[3]。现在，肿瘤局限的患者可以获得65%～70%的5年生存率，这也就意味着仍有很多患者在5年内会复发[4-5]。骨肉瘤发病特点是绝大多数骨肉瘤在诊断时已经成为高等级的恶性肿瘤，而且极易发生早期转移，最常见的转移部位是肺，约占90%[6]。早期转移是导致肿瘤预后差的一个重要因素，发生转移的患者长期生存率仅为10%～30%；其它影响预后的指标包括原发肿瘤的大小和部位，对化疗的敏感性以及手术效果。骨肉瘤的原发病灶患者生存率在65%左右，一旦出现转移，骨肉瘤的生存率只有25%，甚至更低[7]。随着对骨肉瘤的认识的不断深入，骨肉瘤的转移侵袭机制也越来越多的成为研究的重点，本报道通过不同的研究方向，对骨肉瘤的转移相关机制进行综述。Osteosarcoma （ OS ） is the most common primary malignant bone tumor in the children and adolescent, with poor prognosis as a result of early metastasis and relapse. The 5-year disease-free survival rate in the patients with localized disease has been greatly improved since the invention of preoperative and postoperative chemotherapy. However, the prognosis for the patients with metastatic OS remains poor, and the 5-year disease-free survival rate is no more than 20%. In recent years, numerous investigations about the mechanism of metastasis or invasion of OS spring up. A consensus has been reached that microRNA, lncRNA, DNA and related proteins are involved in this process. A study on the intrinsic mechanism of these factors in OS will stimulate new points of view and lead to new breakthrough directions.

关 键 词：骨肉瘤 肿瘤转移 肿瘤侵润 肉瘤 

分 类 号：R738.1[医药卫生—肿瘤]