溃疡性结肠炎PTPN2和NF-κB单核苷酸多态性的研究进展  

PTPN2 and NF-κB single nucleotide polymorphisms associated with susceptibility to ulcerative colitis

作　　者：刘昌恩 黄玉红[1] 

机构地区：[1]中国医科大学附属第一医院消化内科,辽宁省沈阳市110001

出　　处：《世界华人消化杂志》2015年第1期71-77,共7页World Chinese Journal of Digestology

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种发病机制尚不十分明确且病情反复的肠道疾病.目前众多学者认为,UC是遗传易感性、环境暴露、胃肠道菌群失调及炎症过度反应的共同作用后的结果.非受体型蛋白酪氨酸磷酸酶2(protein tyrosine phosphatase nonreceptor type 2,PTPN2)和核因子-κB(nuclear factor kappa B,NF-κB)在炎症中均扮演重要的角色.这两种炎症因子在UC的发生与发展过程中也起到了重要的作用.近些年,UC基因多态性研究已成为热点,西方人群中UC与PTPN2和NF-κB单核苷酸多态性(single nucleotide polymorphism)的相关性多有报道,我国南方地区也有报道但结果存在争议.现就UC易感基因:PTPN2和NF-κB的基因多态性进行综述.Ulcerative colitis （UC） is a form of chronic and recurrent bowel disease with unknown etiology. Pieces of evidence suggest that UC should be evolved as a result of inappropriate and ongoing activation of the mucosal immune system driven by the luminal commensal microflora in a genetically susceptible host. Protein tyrosine phosphatase non-receptor type 2 （PTPN2） and nuclear factor-kappa B （NF-κB） play important roles not only in inflammatory pathways, but also in the development of UC. In recent years, association of PTPN2 and NF-κB gene polymorphisms with susceptibility to UC has become a research focus in Western counties, but the studies are controversial in southern China. This paper reviews the PTPN2 and NF-κB gene single nucleotide poly- morphisms （SNPs） associated with susceptibility to UC.

关 键 词：非受体型蛋白酪氨酸磷酸酶2 核因子-ΚB 单核苷酸多态性 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]