多层螺旋CT灌注成像对胃癌病理分化程度评估的研究  

Research of multi-slice spiral CT perfusion imaging in evaluating the degree of pathological differentiation of gastric carcinoma

作　　者：朱勇[1] 何光武[1] 傅燕飞[1] 王斌[1] 陆峻[1] 陈尚凡 

机构地区：[1]上海市第一人民医院宝山分院放射科,上海200940

出　　处：《实用放射学杂志》2015年第1期75-77,86,共4页Journal of Practical Radiology

基　　金：上海市宝山科学技术委员会（局级）科研基金项目（10-E-19）。

摘　　要：目的：探讨多层螺旋 CT（MSCT）灌注成像参数与不同分化程度胃癌的相关性。方法用 MSCT 对经手术病理证实的44例胃癌患者术前行灌注扫描,获得灌注参数值,包括血流量（BF）、Patlak 血容量（PBV）、达峰时间（TTP）和 Patlak 表面通透性（PPS）；根据肿瘤细胞不同分化程度分成2组：高分化组26例与低分化组18例,再比较2组病例灌注参数值的差异。结果高分化组胃癌灌注参数：BF 值（mL·min^-1·100 mL^-1）101.8±6.7,PBV 值（mL/1000 mL）85.9±3.4,TTP 值（0.1 s）121.6±11.5, PPS 值（0.5 mL·min^-1·100 mL^-1）82.7±11.0；低分化组胃癌灌注参数：BF 值105.3±7.7,PBV 值92.1±7.1,TTP 值113.0±10.5,PPS 值94.3±22.9。BF 值在胃癌不同分化2组间差异无统计学意义（P 〈0.05）,TTP,PBV,PPS 值在2组间差异均有统计学意义（P 〈0.05）。结论MSCT 灌注参数值在一定程度可反映活体上的胃癌肿瘤恶性程度。Objective To evaluate the correlation between multi-slice spiral CT（MSCT）perfusion imaging parameters and gastric carcinoma differentiation.Methods MSCT perfusion parameters including blood flow（BF）,patlak blood volume（PBV）,time to peak （TTP）and patlak permeability surface（PPS）were obtained in 44 patients with pathologically confirmed gastric carcinoma before sur-gery.Patients were divided into two groups;26 well differentiated and 18 poorly differentiated.According to the extent of cell differ-entiation ,BF,PBV,TTP and PPS were investigated in two groups.Results Parameters in the well differentiated gastric carcinoma group BF 101.8±6.7 （mL·min^-1 ·100 mL^-1 ）,PBV 85.9±3.4 （mL/1 000 mL ）,TTP 121.6±1 1.5（0.1 s）,PPS 82.7±1 1.0 （0.5 mL·min^-1 ·100 mL^-1 ）respectivily,Parameters in the poorly differentiated gastric carcinoma group,BF 105.3 ±7.7,PBV 92.1±7.1,TTP 113.0±10.5,PPS 94.3±22.9 respectivily.There was no statistic difference in BF value between the two groups（P 〈0.05）. There were statistic differences in TTP、PBV and PPS between the two groups（P 〈0.05）.Conclusion MSCT perfusion parameters may reflect the degree of differentiation of gastric carcinoma or a certain extent in vivo.

关 键 词：胃癌 计算机体层成像 灌注成像 

分 类 号：R735.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]