1％环戊通对近视儿童睫状肌麻痹效果的观察  

Observation of the cycloplegic effects of 1% cyclopentolate on myopic children

作　　者：郭继援 李仕明[1,2,3] 李翯[4] 刘洛如 李偲圆[1,2,3] 康梦田[1,2,3] 孙芸芸[1,2,3] 贾琳[4] 姬亚洲 

机构地区：[1]首都医科大学附属北京同仁医院,100730 [2]北京同仁眼科中心,100730 [3]北京市眼科学与视觉科学重点实验室,100730 [4]河南省安阳市眼科医院,455000

出　　处：《中华眼视光学与视觉科学杂志》2015年第2期96-98,共3页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：国家自然科学基金（81300797）;国家自然科学基金重大国际合作项目（81120108007）;国家973重点基础研究发展计划项目（2011CB504601）;北京市科技新星（Z121107002512055）作者单位：（李仕明、李偶圆、康梦田、孙芸芸）;455000河南省安阳市眼科医院（郭继援、李鬻、刘洛如、贾琳、姬亚洲）通信作者：李仕明,Email：[e-mail]

摘　　要：目的 通过客观法测量残余调节,明确1％环戊通对近视儿童睫状肌的麻痹效果.方法 系列病例研究.共纳入40例儿童,平均年龄（12.5±2.0）岁,右眼等效球镜度平均为（-2.52±1.05）D.采用1％环戊通对受检者点眼3次,每次间隔5 min.在点眼前及第3次点眼后25、50、75、100、125 min时,嘱其分别注视6 m和33 em处的视标,使用开放视野电脑验光仪WAM-5500测量调节反应,二者差值为残余调节.采用重复测量的方差分析对各个时间点之间的差异进行比较.结果 在散瞳前后共6个时间点,受检者视远时的调节反应分别为（0.27±0.79）D、（0.20±0.73）D、（0.14±0.61）D、（0.08±0.52）D、（0.11±0.40）D和（0.09±0.56）D,各个时间点之间差异有统计学意义（F=6.18,P＜0.05）.视近时的调节反应分别为（1.15±0.98）D、（0.42±0.81）D、（0.34±0.80）D、（0.16±0.69）D、（0.31±0.61）D和（0.32±0.76）D,各个时间点之间差异有统计学意义（F=5.25,P＜0.05）.残余调节量分别为（0.88±0.73）D、（0.22±0.55）D、（0.20±0.56）D、（0.08±0.61）D、（0.19±0.48）D和（0.24±0.45）D,各个时间点之间差异有统计学意义（F=7.28,P＜0.05）.结论 1％环戊通可有效麻痹8～15岁近视儿童的睫状肌,在75 min左右效果最强,3次点眼后25 min至2h内验光相对较为准确。Objective To determine the cycloplegic effects of 1% cyclopentolate on myopic children,using residual accommodation as an objective measurement.Methods A total of 40 children with a mean age of 12.5±2.0 years were included in this case series study.Mean spherical equivalent of the right eyes was-2.52±1.05 D.One percent cyclopentolate was administered 3 times at 5 min intervals.After the third installation,far and near accommodative responses were measured at 25 rmin,50 min,75 min,100 min,and 125 min using an open-field autorefractor （Grand-Seiko,WAM-5500）.The difference in the accommodative response between these 6 m and 33 cm was considered to be residual accommodation.Repeated measurement was used to evaluate the differences at the different time points.Results The respective distance accommodative responses at the 6 time points were 0.27±0.79 D,0.20±0.73 D,0.14±0.61 D,0.08±0.52 D,0.11±0.40 D and 0.09±0.56 Dand the differences were significant （F=6.18,P〈0.05）.The respective near accommodative responses were 1.15±0.98 D,0.42±0.81 D,0.34±0.80 D,0.16±0.69 D,0.31±0.61 D and 0.32±0.76 D and the differences were significant （F=5.25,P〈0.05）.The respective residual accommodations were 0.88±0.73 D,0.22±0.55 D,0.20±0.56 D,0.08±0.61 D,0.19±0.48 D and 0.24±0.45 D,and the differences were significant （F=7.28,P〈0.05）.Conclusion 1% cyclopentolate is effective in paralyzing the ciliary muscle of myopic children aged 8-15 years,and reaches the strongest effect at 75 min.It is relatively accurate to finish refractions between 25 min and 2 hours after the last installation of 1% cyclopentolate.

关 键 词：睫状肌麻痹 环戊通 调节 眼 近视 

分 类 号：R778.11[医药卫生—眼科]