原发性开角型青光眼患者与正常人黄斑区脉络膜厚度的比较  

Comparison of macular choroidal thickness between primary open angle glaucoma and normal subjects

作　　者：张苗苗[1] 王建荣[1] 刘伟[1] 

机构地区：[1]济南市第二人民医院眼科,山东济南250001

出　　处：《山东大学学报（医学版）》2015年第2期71-74,共4页Journal of Shandong University:Health Sciences

摘　　要：目的研究原发性开角型青光眼(POAG)患者黄斑区脉络膜厚度与正常人之间的差异。方法应用增强深部成像的相干光断层扫描(EDI-OCT)仪测量60例(60只眼)POAG患者(POAG组)和60例(60只眼)正常人(对照组)黄斑区脉络膜厚度。组内相关系数(ICC)表示检测者内和检测者间信度分析。结果检测者内的ICC值为0.994~0.999(P<0.001),检测者间的ICC值为0.995~0.998(P<0.001)。黄斑区脉络膜厚度特征为黄斑中心凹下方最厚,鼻侧最薄。POAG组黄斑区各象限脉络膜厚度均明显厚于对照组(t=3.114~4.456,P<0.05)。POAG组和对照组黄斑区象限脉络膜厚度均随年龄增加及眼轴增长而变薄(r=-0.456^-0.520,-0.445^-0.491;P<0.05)。结论 POAG患者的黄斑区脉络膜厚度比正常人厚;POAG患者黄斑区脉络膜增厚与青光眼的发病机制相关。Objective To compare the macular choroidal thickness between primary open angle glaucoma （POAG）and normal subjects using enhanced depth imaging optical coherence tomography （EDI-OCT）.Methods Scans were per-formed by EDI-OCT in eyes of 60 POAG patients and 60 age-and sex-matched normal subjects.The reliability analysis of intra-and inter-observer was tested using intraclass correlation coefficient （ICC）.Results The intra-and inter-ob-server ICC values ranged from 0.994 to 0.999 and 0.995 to 0.998 respectively （both P 〈0.001）.In the COPD pa-tients and controls,the choroidal thickness beneath the fovea was thickest and the nasal choroidal thickness was thin-nest.Each quadrant of choroidal thickness in POAG patients were thicker than that of the controls （t =3.114 to 4.456, P 〈0.05）.For both subjects investigated,the choroidal thickness showed a negative correlation with age and axial length （r =-0.456 to -0.520,-0.445 to -0.491;P 〈0.05）.Conclusion The choroidal thickness of POAG pa-tients is thicker than that of the controls,and the thickening choroidal thickness in POAG patients is associated with the pathogenesis of glaucoma.

关 键 词：青光眼 开角型 脉络膜 体层摄影术 光学相干 

分 类 号：R775[医药卫生—眼科]