未生育女性人群中流产与乳腺癌的关系的Meta分析  

Meta-analysis of the relationship between the breast cancer and abortions among nulliparous women

作　　者：吴秀娟[1] 尚永刚[2] 唐静[1] 谢明均[3] 

机构地区：[1]泸州医学院附属医院普通外科,四川泸州646000 [2]第三军医大学新桥医院,重庆400037 [3]宜宾市第一人民医院普通外科,四川宜宾644000

出　　处：《局解手术学杂志》2015年第1期39-42,共4页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的通过系统评价及Meta分析未生育女性流产与乳腺癌的相关性。方法根据纳入和排除标准,检索Cochrane图书馆、Pub Med数据库(时间截止至2014年6月)关于未生育女性流产和乳腺癌关系的临床队列和病例对照研究文献,运用STATA软件对文献中提供的效应值(RR或OR)及95%采用固定效应模型进行合并。结果最终纳入文献13篇。Meta分析结果显示,在未生育女性人群中,流产与乳腺癌发生率之间无统计学意义,RR=0.98,95%CI为[0.89,1.08],P>0.05,并且流产次数与乳腺癌的发生并无多大关系。其中人流与乳腺癌关系,自然流产与乳腺癌关系的RR及95%CI分别为0.96[0.88,1.04],P>0.05和1.01[0.88,1.14],P>0.05。结论在未生育女性人群中,流产并不增加乳腺癌的发生率,且随着流产次数的增加,乳腺癌发生的风险并不升高。Objective To evaluate the relationship between the risk of breast cancer and abortions among nulliparous women. Methods Searched the data of Cochrane Library and PubMed before June 2014 to identify potentially studies which involved the relationship between the risk of breast cancer and abortions among nulliparous women. Data was extracted by two independent authors from each study. STATA software was used for statistical analysis. Calculated the pooled RR and 95% CI as the assessment of the link between abortions and breast cancer in fixed effects models. Results 13 studies were included. The study showed the RR and 95%CI of the relationship between the risk of breast cancer and abortions was 0. 98[0. 89,1. 08],P〉0. 05 in nulliparous women, and the number of abortions was not associated with the risk of breast cancer. The RR and 95%CI of the relationship between the risk of breast cancer and induced abortions or spontaneous abor-tions were 0. 96[0. 88,1. 04],1. 01[0. 88,1. 14], respectively. Conclusion There is no correlation between breast cancer and abortions a-mong the nulliparous women, and the risk of breast cancer would not increas as the number of abortions increase.

关 键 词：人工流产 乳腺癌 自然流产 未产妇女 

分 类 号：R737.9[医药卫生—肿瘤] R719.3[医药卫生—临床医学]