New progress in active immunotherapy targeting to amyloid beta  

作　　者：Gao Li Yong-Xiang Chen Yan-Mei Li 

机构地区：[1]Key Lab of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education [2]Department of Chemistry, Tsinghua University [3]Beijing Institute for Brain Disorders

出　　处：《Science China Chemistry》2015年第3期383-389,共7页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China(2013CB910700,2012CB821600);the National Natural Science Foundation of China(21472109,21102082);the Research Project of Chinese Ministry of Education(113005A)

摘　　要：Alzheimer's disease(AD) is one of the most common types of dementia whose hallmarks include neurofibrillary tangles and senile plaques. The latter are mainly composed of amyloid-β proteins(Aβ), and it's suggested that Aβ may be the causative factor in AD pathogenesis. Immunotherapy targeting Aβ for preventing aggregation of Aβ and mildly clearing amyloid plaques has been a hot topic since 1999. Although the first clinical trial of Aβ vaccine, AN-1792, failed in phase II, its results suggested some key points in the design of Aβ vaccines. Avoiding the possible toxic Aβ specific T cell response and inducing a Th2 type cellular immune response may be beneficial for Aβ immunotherapy. Many associations and research groups are working on Aβ vaccine and some progress has been made in recent years. In this review, we have provided a detailed summary of past Aβ vaccines, which have been sorted by the immunogen, and we also discuss some recent progress and future perspectives.Alzheimer＇s disease（AD） is one of the most common types of dementia whose hallmarks include neurofibrillary tangles and senile plaques. The latter are mainly composed of amyloid-β proteins（Aβ）, and it＇s suggested that Aβ may be the causative factor in AD pathogenesis. Immunotherapy targeting Aβ for preventing aggregation of Aβ and mildly clearing amyloid plaques has been a hot topic since 1999. Although the first clinical trial of Aβ vaccine, AN-1792, failed in phase II, its results suggested some key points in the design of Aβ vaccines. Avoiding the possible toxic Aβ specific T cell response and inducing a Th2 type cellular immune response may be beneficial for Aβ immunotherapy. Many associations and research groups are working on Aβ vaccine and some progress has been made in recent years. In this review, we have provided a detailed summary of past Aβ vaccines, which have been sorted by the immunogen, and we also discuss some recent progress and future perspectives.

关 键 词：Alzheimer＇s disease amyloid beta active immunotherapy peptide vaccine DNA vaccine 

分 类 号：R749.16[医药卫生—神经病学与精神病学]