川芎清脑颗粒治疗小儿偏头痛临床效果观察  

Efficacy analysis of Chuanxiongqingnaokeli treatment of children with migraine

作　　者：吴琼[1] 范玉颖[1] 张俊梅[1] 杨凤华[1] 刘雪雁[1] 赵亚娟[1] 周晓薇[1] 王华[1] 

机构地区：[1]中国医科大学附属盛京医院小儿神经内科,沈阳110004

出　　处：《中国综合临床》2015年第3期278-281,共4页Clinical Medicine of China

摘　　要：目的观察川芎清脑颗粒治疗d,JI,偏头痛的临床效果和不良反应。方法选取100例偏头痛患儿应用随机数字表法分成观察组50例和对照组50例。观察组给予川芎清脑颗粒10g／次口服，3次／d。对照组给予盐酸氟桂利嗪胶囊2．5mg／次口服，体质量〉50kg给予5．0mg／次，每晚1次。两组均以治疗3个月为1个疗程，治疗3个疗程后对比两组的疗效。结果两组治疗后血流速度指标与治疗前相比均有下降，但观察组的血流速度值[ACA（81．10±11．95）、MCA（93．30±14．16）、PCA（70．20±11．57）、BA（70．60±13．02）、VA（65．50±12．60）cm／s]较对照组[ACA（104．20±12．63）、MCA（116．20±15．82）、PCA（93．50±11．91）、BA（93．50±12．71）、VA（87．40±12．92）cm／s]降低更为显著，差异均有统计学意义（P均〈0．05）。观察组发作次数（1．0±0．6）次及持续时间（3．3±1．0）h较对照组发作次数（2．3±0．9）次及持续时间（5．6±1．7）h低，观察组改善情况显著优于对照组（t值分别为-3．345、-3．269，P均〈0．05）。观察组有效率90％（45／50），对照组有效率74％（37／50），两组比较差异有统计学意义（x2=4．336，P〈0．05）。两组均未发生严重的不良反应。结论川芎清脑颗粒治疗小儿偏头痛安全有效。Objective To observe the clinical efficacy and adverse reaction of Chuanxiongqingnaokeli for children with migraine. Methods One hundred children patients with migraine were randomly divided into treatment group （ n = 50） and control group （ n = 50） . Patients in treatment group were given Chuanxiongqingnaokeli,10 g/once, and three times one day, while in control group were given Flunarizine Hydrochloride Capsules,2.5 mg/once, and who＇s body mass 〉 50 kg with 5.0 mg/once, and one times each night. Three months as one course of treatment, and compared the efficacy of two groups after tree course of treatment. Results The hemodynamics of two groups all decreased after treatment compared with before treatment,but ACA, MCA, PCABA and VA in treatment group （（ 81.10 ± 11.95 ）, （93.3 ±14. 16）, （70. 2 ± 11.57）, （70.6 ± 13.02）, （65.5 ±12. 6） cm/s respectively） decreased more significantly than that of control group（（104.2 ±12.63）, （116.2± 15.82）, （93.5 ±11.91）, （93.5 ± 12.71）,87.4± 12.92） cm/s respectively） , and the differences were significant （P 〈 O. 05 ）. The headache frequency and duration in treatment group were （ 1.0 ± 0. 6） and （ 3.3 ± 1.0 ）, less than that of control group （ （ 2. 3±0. 9） and （ 5.6 ± 1.7 ） ; t = - 3. 345, - 3. 269 ; P 〈 0. 05 ）. The total effective rate in treatment group was 90.0% （ 45/50 ）, higher than that of control group（74. 0% （37/50） ;X2 = 4. 336, P 〈 0.05 ）. There was no severe adverse reaction in both two groups. Conchmion The Chuanxiongqingnaokeli is safe and effective for treatment of children with migraine.

关 键 词：川芎清脑颗粒 偏头痛 盐酸氟桂利嗪 

分 类 号：R748[医药卫生—神经病学与精神病学]