Ezrin在软组织肉瘤中的表达意义及其预后相关性分析  

The correlation of Ezrin expression and comprehensive analysis with prognosis in soft tissue sarcoma

作　　者：锡林宝勒日 董超[1] 鲁学良[1] 李勇奇[1] 

机构地区：[1]新疆医科大学附属肿瘤医院骨与软件组织病区,新疆乌鲁木齐830000

出　　处：《中国肿瘤外科杂志》2015年第1期20-23,共4页Chinese Journal of Surgical Oncology

摘　　要：目的探究Ezrin在不同软组织肉瘤中的表达水平及其与肿瘤术后复发的相关性。方法采用组织芯片、二步法免疫组织化学染色法对94例软组织肉瘤中Ezrin的表达情况进行检测,分析其与软组织肉瘤术后复发之间的相关性。结果 Ezrin高表达的软组织肉瘤患者术后复发率显著高于Ezrin低表达组(P=0.026,OR=10.301)。在亚组单变量分析中,在年龄≤60岁、部位为四肢肉瘤、切缘阴性、不同肿瘤大小、不同性别、不同恶性度、不同化疗及放疗状态下,Ezrin不同表达水平的软组织肉瘤复发率均不同,差异均为P<0.05。结论 Ezrin可作为软组织肉瘤复发的独立预测因子,可作为候选标记物指导软组织肉瘤患者的预后治疗。Objective To investigate the expression level of Ezrin in soft tissue sarcomas and the prognosis value in postoperative recurrence. Methods Analyzing the specimens from 94 patients suffered from soft tissue sarcomas. Tissue microarrays were constructed with representative tumor areas. Immunohistochemistry from PV-6000 polymer detection system was used to evaluate he expression of Ezrin and to analyze the relationship between the expression of Ezrin and recurrence after operation from 94 soft tissue sarcomas patients. Results Compared with the group with low expression of Ezrin,there was a high recurrence rate in the group of high expression of Ezrin,and the result was significant different（ P = 0. 026,0R = 10. 301）. In subgroup univariate analysis,the recurrence rate varied with the expression of Ezrin on the patients under 60 years old who suffered from extremity malignant tumor and negative margin,regardless of the gender,tumor size,grade nor chemotherapy（ P〈0. 05）. Conclusions High expressions of Ezrin occurred in soft tissue sarcomas patients with negative margin and can be treated as an independent predictor of recurrence and it can guide the preoperative evaluation and treatment on patients with soft tissue sarcomas.

关 键 词：EZRIN 免疫组化 术后复发 软组织肉瘤 

分 类 号：R738.6[医药卫生—肿瘤]