声门上型喉癌中环氧化酶-2的表达及与微血管和淋巴管密度的关系  

The expression of COX-2 and its relationship with microvessel density and lymphatic vessel density in supraglottic laryngeal carcinoma

作　　者：王智勇[1] 成伟[1] 梁中敏[1] 刘维奇[1] 潘祖远[1] 梁滔[1] 

机构地区：[1]南方医科大学附属南海医院耳鼻咽喉科,广东佛山528200

出　　处：《中国肿瘤外科杂志》2015年第1期27-29,32,共4页Chinese Journal of Surgical Oncology

基　　金：佛山市科技攻关项目立项课题(No.201108148)

摘　　要：目的探讨环氧化酶-2(cyclooxygenase-2,COX-2)在声门上型喉癌的表达与微血管密度(microvessel density,MVD)、淋巴管密度(lymphatic vessel density,LVD)的关系及其临床意义。方法通过免疫组化SP法对64例声门上型喉癌标本中COX-2进行检测,同时标记CD34和D2-40用以分别检测喉癌组织中MVD和LVD。结果该组喉癌中COX-2表达阳性率为70.31%,MVD为36.79±8.48,LVD为9.79±6.35。COX-2的表达与患者性别、年龄、肿瘤组织学分级无关(P>0.05),而与肿瘤临床分期和淋巴结转移相关(P<0.05),COX-2表达阳性组MVD及LVD高于COX-2表达阴性组,差异有统计学意义(P<0.05)。结论 COX-2可能参与喉癌发生并促进血管及淋巴管生成,影响肿瘤的转移、进展和预后。Objective To study the expression of cyclooxygenase-2（ COX-2） and its correlation with microvessel density（ MVD） and lymph vessel density（ LVD） in supraglottic laryngeal carcinoma,as well as to analyze the clinicopathological significance. Methods The expression COX-2 were detected by SP immunohistochemical staining in 64 case patients of supraglottic laryngeal carcinoma,CD34 and D2-40 marking were used to measure the MVD and LVD. Results The positive rate of COX-2 was 70. 31%,MVD was 36. 79 ± 8. 48,LVD was 9. 79 ±6. 35. The expression of COX-2 were closely associated with clinical stage and lymphatic metastasis（ P〈0. 05）,but not related with age,sex and histological grade of the tumor（ P〉0. 05）. The MVD and LVD of cases with positive COX-2 expression was significantly higher than those without COX-2 expression（ P〈0. 05）. Conclusion COX-2 may contribute to tumorigenesis and may have a function on promoting angiogenesis and lymphangiogenesis in supraglottic laryngeal carcinoma,hence affect tumor metastases,progression and prognosis.

关 键 词：喉癌 声门上型 环氧化酶-2 微血管密度 淋巴管密度 

分 类 号：R739.65[医药卫生—肿瘤]