肝硬化患者健康相关生存质量与生存时间的关系  

Relationship between health-related quality of life and survival time in patients with liver cirrhosis

作　　者：高峰[1] 李光[1] 高茹[1] 

机构地区：[1]首都医科大学附属北京朝阳医院消化内科,北京100020

出　　处：《胃肠病学和肝病学杂志》2015年第1期49-52,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的研究肝硬化患者健康相关生存质量与生存时间的关系。方法所有受试者回答SF-36 v2(中文版)量表,通过SF-36 v2软件计算出基线:生理功能、生理职能、躯体疼痛、总体健康、活力、社会功能、情感职能、精神健康共8个维度,以及躯体健康总评和精神健康总评评分。同时登记所有受试者入选时的一般资料和临床资料。随访时间为18个月。Cox回归分析和KaplanMeier分析进行生存分析。结果 221例肝硬化患者完成调查。随访期间50例患者死亡。存活组SF-36各维度评分均高于死亡组(P<0.05)。存活组躯体健康及精神健康总评评分较死亡组高(P<0.001)。Cox回归分析及Kaplan-Meier分析均显示,躯体健康总评和精神健康总评评分越高肝硬化受试者生存时间越长。结论肝硬化患者健康相关生存质量与生存时间密切相关。健康相关生存质量可以用来预测肝硬化患者的生存时间。Objective To investigate the relationship between health-related quality of life （ HRQOL） and survival time in Chinese patients with liver cirrhosis. Methods HRQOL was measured with Short Form 36 （ SF-36 ） Chinese version. SF-36 scores, demographic and clinical data were collected at baseline. Follow-up was 18 months. Cox regres-sion and Kaplan-Meier analysis were conducted. Surviving patients were censored in the analysis. Results A total of 221 patients with liver cirrhosis were enrolled. During the follow-up period, 50 patients died. SF-36 score in survival group was higher than death group. Scores of physical component summary （ PCS ） and mental component summary （MCS） in survival group were higher than death group （P〈0. 001）. Cox regression analysis and Kaplan-Meier analysis both showed that survival time was significantly associated with better PCS and MCS scores. Conclusion HRQOL was related with survival time in patients with liver cirrhosis. HRQOL could be used to predict survival time in patients with liver cirrhosis.

关 键 词：健康相关生存质量 肝硬化 简明量表SF-36 生存时间 

分 类 号：R575.2[医药卫生—消化系统]