脂联素在重症急性胰腺炎脂肪组织中的表达及意义  

Expression and significance of adiponectin in severe acute pancreatitis of the rats' adipose tissue

作　　者：韩超群[1] 杨芬[1] 刘俊[1] 钱伟[1] 丁震[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科,湖北武汉430022

出　　处：《胃肠病学和肝病学杂志》2015年第1期75-77,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金资助项目(30900664;81470039;81170373)

摘　　要：目的探讨脂联素在重症急性胰腺炎(severe acute pancreatitis,SAP)脂肪组织中的表达、作用及意义。方法通过牛磺胆酸钠诱导建立大鼠SAP模型,12只SD大鼠随机分成2组:假手术对照组(N组)、SAP组;分别于24 h内处死,取附睾旁脂肪组织,采用RT-PCR行mRNA表达量检测,HE染色观察脂肪组织炎症改变情况。结果与N组相比,SAP组炎症因子IL-10、TNF-αmRNA表达上升(P<0.05),而TGF-β1及脂联素的表达明显下降(P<0.01)。结论脂联素在SAP中起保护性作用,有可能成为预测SAP严重程度及判断预后的指标。Objective To investigate the expression and significance of adiponectin in severe acute pancreatitis （ SAP） of the rats’ adipose tissue. Methods Rats were reduced by retrograde injection of sodium deoxycholate into the biliary-pancreatic duct. Twelve SD rats were randomly divided into two groups： sham operation group （ N group, n=6）, SAP models group （SAP group, n=6）. All rats were killed in 24 hours after operation and got adipose tissue next epididymis. The mRNA expression were detected by RT-PCR. The adipose tissue injuries were evaluated by pathological changes. Results Compared with N group, pathological changes were more seriously, the mRNA expression of adi-ponectin in SAP group significantly reduced （ P〈0 . 01 ） , and markly higher than that of IL-10 , TGF-β1 , TNF-α（ P〈0. 05）. Conclusion Adiponectin plays a protective role in the progression of SAP. It may be useful to predict the se-verity and prognosis of SAP.

关 键 词：脂肪细胞因子 脂联素 急性重症胰腺炎 

分 类 号：R576[医药卫生—消化系统]