FAK与肿瘤关系的研究进展  

Research progress on the relationship between FAK and cancer

作　　者：李玲妹[1] 曹文枫[1] 

机构地区：[1]天津医科大学肿瘤医院病理科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2015年第2期116-119,共4页Chinese Journal of Clinical Oncology

摘　　要：着斑激酶(focal adhesion kinase,FAK)是一种细胞质内的蛋白酪氨酸激酶(protein tyrosine kinase,PTK),因其与细胞粘附功能密切相关而得名。近年来,人们对FAK的了解逐渐深入,国内外大量研究表明FAK在多种肿瘤组织中表达增高,并与肿瘤的多个过程有着密切的关系。FAK已经成为新的肿瘤治疗靶点之一,为肿瘤的治疗带来新的方法和希望。Focal adhesion kinase （FAK）, a type of protein tyrosine kinase in the cytoplasm, is highly expressed in many types of malignant tumors. FAK is named as such because of its close relationship with the cell adhesion function. Recent studies show that FAK is expressed in many tumor cells and has a definite relationship with cancer progress, metastasis, and prognosis. Accordingly, FAK has become one of the new tumor therapeutic targets that will bring new methods for tumor therapy.

关 键 词：粘着斑激酶 肿瘤 转移 凋亡 

分 类 号：R730.2[医药卫生—肿瘤]