食管鳞状细胞癌间质细胞中podoplanin的表达及临床意义  

Expression of podoplanin-positive stromal cells in esophageal squamous cell carcinoma and its clinical significance

作　　者：梁晓东[1] 黄文斌[2] 王劲松[2] 

机构地区：[1]江苏省盐城市第三人民医院病理科,盐城224000 [2]南京医科大学附属南京医院(南京市第一医院病理科),南京210006

出　　处：《临床与实验病理学杂志》2015年第2期128-131,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：南京市卫生青年人才基金(QRX11093)

摘　　要：目的观察食管鳞状细胞癌间质细胞中podoplanin的表达及与临床病理特征的关系,探讨podoplanin阳性间质细胞在食管鳞状细胞癌进展中的作用。方法应用免疫组化En Vision法检测69例食管鳞状细胞癌中podoplanin的表达,分析阳性间质细胞中podoplanin表达与食管鳞状细胞癌临床病理特征的关系。结果 69例食管鳞状细胞癌中,间质细胞podoplanin阳性者43例,阳性率为62.3%。食管鳞状细胞癌中间质细胞podoplanin阳性者淋巴管密度(lymphatic vessel density,LVD)为45.72±14.36,明显高于间质细胞podoplanin阴性者(21.23±10.49),差异有统计学意义(P<0.01);有淋巴管侵犯的食管鳞状细胞癌间质细胞podoplanin表达明显高于无淋巴管侵犯者(P<0.05)。间质细胞podoplanin表达与患者年龄、性别、肿瘤大小、浸润深度、分化程度、淋巴结转移和临床分期均无关(P>0.05)。结论 podoplanin阳性间质细胞可促进食管鳞状细胞癌淋巴管形成和淋巴管侵犯。Purpose To study the correlation between the expression of podoplanin-positive stromal cells and clinicopathologic features in squamous cell carcinoma （ SCC） of esophagus, and to explore the role of podoplanin-stromal cells in the progression of SCC of e-sophagus. Methods Immunohistochemical EnVision method was used to detect the expression of podoplanin in the stromal cells of e-sophageal SCC. The correlation between the expression of podoplanin-positive stromal cells and clinicopathologic features in SCC of e-sophagus was analyzed. Results Of 69 cases of SCC, podoplanin-positive stromal cells were seen in 43 and the positive rate was 62. 3%. Lymphatic vessel density in SCCs with podoplanin-positive stromal cell was 45. 72 ± 14. 36, which was higher than that with-out podoplanin-positive stromal cell （21. 23 ± 10. 49） （P〈0. 01）. Expression of podoplanin in stromal cells in SCCs with lymphatic vessel invasion was higher than those without lymphatic vessel invasion （P〈0. 05）. There was no correlation between podoplanin-posi-tive stromal cells and age, sex, tumor size, the depth of invasion, differentiation, lymph node metastasis, and clinical stage （ P〉0. 05）. Conclusion Podoplanin-positive stromal cells may promote the lymphangiogenesis and lymph vessel invasion of esophageal SCC.

关 键 词：食管肿瘤 鳞状细胞癌 PODOPLANIN 间质细胞 

分 类 号：R735.2[医药卫生—肿瘤]