炎症因子与帕金森病幻觉的相关性  

A study on the association between the inflammatory factors and hallucination in patients with Parkinson disease

作　　者：王玉华[1] 时兴华[1] 

机构地区：[1]德州市人民医院神经内科,德州253014

出　　处：《中国神经精神疾病杂志》2015年第1期1-4,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的通过对帕金森病（Parkinson disease,PD）患者发生幻觉的调查,探讨幻觉的发生率及其影响因素。方法选取神经内科门诊及住院的91例PD患者和38名健康体检者为研究对象。进行简易智力检查量表（mini-mental state examination,MMSE）,综合评分量表第Ⅲ部分（unified Parkinson disease rating scale-Ⅲ,UPDRS-Ⅲ）以及Hoehn-Yahr分期检查,测量白介素6（interleukin 6,IL-6）和C反应蛋白（C-reactive protein,CRP）。采用帕金森精神症调查问卷（Parkinson psychosis questionnaire,PPQ）B类对PD患者进行分组,PPQ-B≥1分为幻觉组,PPQ-B=0分为无幻觉组。采用logistic回归分析方法探讨其影响因素。结果 91例PD患者中有29例出现幻觉,发生率为32%。幻觉组的年龄、IL-6和CRP高于无幻觉组和正常对照组（P〈0.05）,幻觉组的病程和MMSE高于无幻觉组（P〈0.05）。经Logistic回归分析发现,年龄和病程是幻觉的独立危险因素,比值比（Odds Ratio,OR）分别为1.09（95%CI：1.04~1.32,P〈0.05）和1.43（95%CI：1.21~1.87,P〈0.05）。炎症因子IL-6每增加1倍,幻觉危险性增加51%（OR=1.51,95%CI：1.13~2.11,P〈0.05）,CRP每增加1倍,幻觉危险性增加59%（OR=1.59,95%CI：1.07~2.66,P〈0.05）。结论控制血清IL-6和CRP水平,对于延迟或阻止PD患者发生幻觉具有重要意义。ObjectiveTo investigate the incidence and risk factors of hallucination in patients with Parkinson＇s disease（PD） by using a questionnaire.MethodsNinety-one patients with PD from outpatient and inpatient departments of Neurology and 38 healthy subjects were recruited. Mini-mental state examination（MMSE）, unified Parkinson＇s disease rating scale- Ⅲ（UPDRS-Ⅲ）, Hoehn-Yahr, interleukin 6（IL-6） and C-reactive protein（CRP） were examined in all PD.According to the PPQ-B scores, the PD patients were divided into two groups： the hallucination group（PPQ-B≥1） and non-hallucination group（PPQ-B=0）. Logistic regression model was used to explore the risk factors.ResultsTwenty-nine of 91 patients had hallucination and the incidence was 32%. Age and the levels of IL-6 and CRP were significantly higher in hallucination group than in non-hallucination group. Meanwhile, the duration of illness and MMSE were significantly higher in hallucination group than in non-hallucination group. Logistic regression revealed that the age and duration of illness were independent risk factors of hallucination and the Odds Ratios（OR） were 1.09（95% CI：1.04~1.32, P〈0.05） and 1.43（95% CI：1.21~1.87, P〈0.05）, respectively. The risk of hallucination increased by 51% and 59%for each doubling of IL-6 and CRP levels in PD patients and the ORs were 1.51（95% CI：1.13~2.11, P〈0.05） and 1.59（95% CI：1.07~2.66, P〈0.05）, respectively.ConclusionsControlling the levels of serum IL-6 and CRP plays an important role in delay or prevention of the hallucination of PD patients.

关 键 词：帕金森病 幻觉 C反应蛋白 白介素6 

分 类 号：R742.5[医药卫生—神经病学与精神病学]