骨髓间充质干细胞旁分泌因子治疗重症急性胰腺炎的潜能  

Potential Therapeutic Effect of Paracrine Factors from Bone Marrow-derived Mesenchyme Stem Cells in the Treatment of Severe Acute Pancreatitis

作　　者：陈珂玲(综述)[1] 周总光(综述)[1] 周斌(综述)[1] 李园(审校)[1] 

机构地区：[1]四川大学生物治疗国家重点实验室,消化外科研究室,成都610041

出　　处：《生物医学工程学杂志》2015年第1期245-248,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点资助项目(30830100);国家自然科学基金资助项目(30972924,81170439);教育部留学回国人员科研启动基金资助项目(20101174-4-2);高等学校博士学科点专项科研基金资助项目(200806100058)

摘　　要：骨髓间充质干细胞(BMSC)移植是重症急性胰腺炎(SAP)治疗的研究热点。但在临床应用中,该治疗方式却遇到了诸多技术及伦理问题。BMSC的旁分泌因子具有与细胞移植同样的疗效,且可减少上述生物安全问题,具有更安全、更易操控的治疗优势。本文就BMSC旁分泌因子在SAP中的治疗潜能作一综述,注射含旁分泌因子的BMSC培养上清有望成为未来SAP细胞治疗的新策略。Bone marrow-derived mesenchymal stem cell（BMSC）transplantation is one of the most popular therapeutic measures in severe acute pancreatitis（SAP）.However,technical challenges and ethical concern have hindered its clinical application.Paracrine factor,as a new safe and easy handing therapeutic measure,can work comparably effective as BMSC transplantation in SAP therapy,but bio-safe risks could be greatly reduced.In this paper,we reviewed the therapeutic effect and potential mechanism of paracrine factors in the treatment of SAP.The injection of paracrine factors yielded from cultured cell suspension will be a new cell therapeutic measure for SAP.

关 键 词：重症急性胰腺炎 骨髓间充质干细胞 旁分泌因子 

分 类 号：R57[医药卫生—消化系统] Q28[医药卫生—内科学]