黛力新与多塞平治疗脑卒中后抑郁的对照研究  

A comparative study of deanxit and doxepin in treatment of post-stroke depression

作　　者：刘琴[1] 李春燕[1] 方岩[1] 

机构地区：[1]商丘市第一人民医院神经内科,476100

出　　处：《中华神经医学杂志》2015年第2期171-175,共5页Chinese Journal of Neuromedicine

摘　　要：目的 探讨黛力新治疗脑卒中后抑郁相对于多塞平的临床优势及安全性。 方法 采取随机数字表法将商丘市第一人民医院神经内科自2010年2月至2014年2月收治的156例脑卒中后抑郁患者分为2组,每组各78例,分别给予黛力新和多塞平治疗8周。采用汉密尔顿抑郁量表（HAMD）、美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数（BI）对2组患者治疗前和治疗后第2、4、8周末的临床疗效进行评估。 结果 黛力新组患者的抑郁程度在治疗后第2周末就有明显改善,HAMD量表评分较多塞平组明显降低,差异有统计学意义（P＜0.05）;在治疗后第4、8周末较多塞平组进一步降低,差异有统计学意义（P＜0.05）。黛力新组临床疗效在治疗后第2、4、8周末与多塞平组比较差异均有统计学意义（P＜0.05）;在治疗第2、4周末黛力新组总有效率为75.0％、90.8％,优于对照组的57。3％、73。3％,差异有统计学意义（P＜0.05）。黛力新组NIHSS评分在治疗后第2周末与多塞平组差异不明显;在治疗后第4、8周末较多塞平组明显降低,差异有统计学意义（P＜0.05）。黛力新组BI指数在治疗后第2、4、8周末均较多塞平组明显升高,差异有统计学意义（P＜0.05）。黛力新组不良反应更少。 结论 黛力新治疗脑卒中后抑郁较多塞平有更好的临床疗效,对神经功能的恢复有明显的促进作用,能明显提高患者的生活质量,且安全性好。Objective To investigate the clinical advantages and safety ofdeanxit treatment on post-stroke depression when comparing with doxepin.Methods One hundred and fifty-six patients with post-stroke depression,admitted to our hospital from February 2010 to February 2014,were randomly divided into deanxit group and doxepin group （n=78）.Both groups were treated with conventional approaches.Furthermore,the deanxit group was given deanxit,while the doxepin group was given doxepin respectively,for 8 weeks.The clinical efficacies were evaluated before treatment,and 2,4 and or 8 weeks after treatment by using Hamilton Depression Rating Scale （HAMD）,US National Institutes of Health Stroke Scale （NIHSS） and Barthel index （BI）.Results Depression of the deanxit group was improved in 2 weeks,with a significant decrease in HAMD scores as compared with the doxepin group （P〈0.05）; the depression degree was further lowered 4 and 8 weeks after treatment （P〈 0.05）.The clinical efficacy between the two groups was significantly different at 2,4 and 8 weeks after treatment; the total effective rates in the deanxit group in 2 and 4 weeks （75.0% and 90.8%） were statistically significantly better than those in the doxepin group （57.3% and 73.3%,P〈0.05）.The neurological deficit scores of the deanxit group were not significantly lower than those in the doxepin group at 2 weeks after treatment,while significant difference was noted at 4 and 8 weeks after treatment （P〈0.05）.The life quality of the deanxit group was significantly improved at 2,4 and 8 weeks after treatment as compared with those in the doxepin group （P〈0.05）.No significant reverse reactions were observed in the deanxit group.Conclusions As compared with the doxepin therapy,deanxit treatment of post-stroke depression has better efficacy,safety and greater promotion on neurological recovery.Furthermore,deanxit can significantly improve the life quality of the patients.

关 键 词：黛力新 多塞平 脑卒中后抑郁 对照研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]