不同分子亚型乳腺癌组织中TRAIL蛋白表达及意义  

Expression of TRAIL in Different Molecular Subtypes of Breast Cancer and Its Clinical Significance

作　　者：陈欣欣[1] 罗海华[2] 张辉[2] 李晓曦[1] 

机构地区：[1]中山大学附属第一医院乳腺外科,广东广州510080 [2]中山大学人类病毒学研究所,广东广州510080

出　　处：《中山大学学报（医学科学版）》2015年第1期65-70,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家科技重大专项课题(2013ZX10001004)

摘　　要：【目的】探讨不同分子亚型乳腺癌组织中TRAIL蛋白(肿瘤坏死因子相关凋亡诱导配体,TRAIL)的表达差异及TRAIL与乳腺癌各临床病理因素之间的关系。【方法】采用streptavidin-perosidase(SP)法检测110例乳腺癌及12例乳腺良性病变组织中TRAIL蛋白的表达水平,分析不同分子亚型乳腺癌组织中TRAIL蛋白表达差异,以及TRAIL表达与乳腺癌临床分期、淋巴结转移以及Ki-67表达等临床因素的关系。【结果】与其他分子亚型相比较,TRAIL蛋白在Luminal B HER-2+型乳腺癌组织中的表达水平明显下调(P=0.035),在Ki-67高表达的乳腺癌组织中也发现了TRAIL表达水平下调(P=0.045),并且TRAIL在乳腺癌组织中的表达水平还受到肿瘤大小、淋巴结状态和TNM分期等因素影响(P=0.004、P=0.006、P=0.001),而不受乳腺癌的病理类型、癌细胞分级、肿瘤有无坏死和神经浸润及患者年龄等因素的影响。【结论】TRAIL蛋白在不同分子亚型乳腺癌组织中的表达有显著差异,并且其与乳腺癌的临床分期、肿瘤大小、淋巴结有无转移等临床特征密切相关,可能有助于判断乳腺癌的预后。【Objective】 To investigate the expression of TNF-related apoptosis-inducing ligand（TRAIL） in breast cancer tissues of different subtypes and the correlation between TRAIL expression and clinicopathological features of breast cancer.【Methods】 The expression of TRAIL was detected by streptavidin-perosidase（SP） in 110 cases of breast cancer and 12 cases of benign breast disorders.TRAIL expression in different molecular subtypes and the relationship between TRAIL expression and clinical staging,lymph node metastasis and Ki-67 expression of breast cancer was studied.【Results】 The expression of TRAIL was significantly decreased in Luminal B HER-2 positive breast cancer tissues compared to that in basal-like breast cancer tissues,HER-2positive breast cancer tissues and luminal-A breast cancer tissues（P = 0.035）.TRAIL expression was also significantly decreased in breast cancer with higher expression of Ki-67（P = 0.045）,The expression of TRAIL in breast cancer was affected by tumor size,lymph node metastasis,clinical stages（P = 0.004,P = 0.006,P = 0.001）,but not by clinicopathological features like pathologic types,cancer cell differentiation,necrosis and age of the patient.【Conclusions】 The expression of TRAIL shows significant difference among different molecular subtypes of breast cancer.It is also correlated with clinical stages,tumor size,lymph node metastasis,which indicates that TRAIL may be a prognostic biological marker in breast cancer.

关 键 词：乳腺癌 TRAIL 分子亚型 临床分期 预后指标 

分 类 号：R737.9[医药卫生—肿瘤]