骨髓间质干细胞在结直肠肿瘤微环境中的作用  

Study on the Role of Mesenchymal Stem Cells in Colorectal Tumor Microenvironment

作　　者：王少川 宋武[1] 

机构地区：[1]中山大学附属第一医院胃肠胰外科,广州510080

出　　处：《医学综述》2015年第3期434-437,共4页Medical Recapitulate

摘　　要：骨髓间质干细胞(MSCs)是由中胚层发育而来的一类成体干细胞,存在于全身结缔组织和器官间质中,属于骨髓非造血干细胞,具有干细胞的一般特性,即自我更新以及多向分化能力。MSCs能够促进结直肠肿瘤的生长。在肿瘤条件下,骨髓中的MSCs随血运迁至肿瘤微环境,参与肿瘤的构建过程。MSCs促进肿瘤侵袭的机制是复杂的,包括MSCs转化为肿瘤相关纤维母细胞参与肿瘤间质的形成以及MSCs对微环境的调节作用。MSCs在结直肠癌靶向治疗策略中的应用前景是广阔的,通过不断的研究,将为MSCs在临床中的安全应用提供新的理论依据。Mesenchymal stem cells（ MSCs） are a type of adult stem cells,which are developed from the mesoderm. They exist in the interstitium of connective tissues and organs in the whole body,and belong to the bone marrow non-hematopoietic stem cells. It has the general characteristics of stem cells,namely the ability of self-renewal and multi-directional differentiation. MSCs could promote the growth of colorectal cancer.Under the condition of tumor,MSCs move along with the blood stream to the tumor microenvironment,and participate in the process of the construction of the tumor. The mechanism of MSCs in promoting tumor invasion is complex,which includes MSCs＇ transformation into tumor associated fibroblast（ TAF） to participate in the formation of stroma and their regulating effect on tumor microenviroment. The application prospect of MSCs in colorectal cancer targeted therapy strategy is extensive,further study in this area will provide new theoretical basis for its safety applications.

关 键 词：结直肠肿瘤 骨髓间质干细胞 肿瘤相关纤维母细胞 

分 类 号：R735[医药卫生—肿瘤]