miR-21在胶质瘤研究和治疗方面的最新进展  

The Latest Progress in Research and Therapy of miR-21 in Glioma

作　　者：李庆腊 宋玉文[1] 李辉[1] 刘晓谦[1] 

机构地区：[1]哈尔滨医科大学附属第四医院神经外科,哈尔滨150001

出　　处：《医学综述》2015年第4期621-624,共4页Medical Recapitulate

摘　　要：胶质瘤是神经外科最常见的恶性肿瘤,其以居高不下的发病率、致死率给患者及家属带来沉重的经济心理负担和巨大的心身伤害。但其治疗近些年却一直徘徊不前,因此迫切需要确定一个新的研究方向和治疗靶点。miR-21是目前的研究热点,多项研究发现miR-21在胶质瘤中高表达,miR-21和细胞凋亡、侵袭性等肿瘤相关因素密切相关。无论体内还是体外实验,人们发现抑制miR-21的表达均可以达到促进细胞凋亡、缩小肿瘤体积的目的,说明miR-21在胶质瘤的发生、发展中有关键作用,miR-21可能成为胶质瘤治疗的新靶点且具有巨大潜力。Glioma is the most common malignant tumor in neurosurgery,with its high mortality and morbidity,it brings heavy psychological-economic burden and huge physical-mental harm to patients and their families. But the treatment has been stagnant in recent years,so there is an urgent need to identify a new research direction and therapeutic target. miR-21 is a hot topic of the field recently. A number of studies have found that miR-21 is over-expressed in glioma,and it is closely related to apoptosis,invasiveness and other tumor-relevant factors.Both in vivo and vitro experiments found that inhibition of miR-21 expression can promote apoptosis and reduce tumor volume,which shows that miR-21 have a key role in the occurrence and development of glioma,and miR-21 may be a new target for the treatment of glioma with great potential.

关 键 词：胶质瘤 微RNA 微RNA-21 

分 类 号：R739.41[医药卫生—肿瘤]