惊跳反射弱刺激抑制(PPI)实验方法的建立与应用——附78例健康成人分析  

The designing and application of prepulse inhibition of the startle reflex: analysis of 78 healthy adults

作　　者：赵亮 周荣山 姚坚 林益强 陈冲[2] 陈兴时[2] 

机构地区：[1]上海市黄浦区精神卫生分中心精神科,上海200122 [2]上海交通大学医学院附属精神卫生中心神经生理室

出　　处：《国际精神病学杂志》2015年第1期4-7,共4页Journal Of International Psychiatry

基　　金：上海市黄浦区科技项目(Hkw2013-20);国家自然科学基金项目(81271480)

摘　　要：目的利用惊跳反射弱刺激抑制（PPI）新技术探讨健康成人感觉门控（SG）的特征。方法应用德国Brain Products公司的脑电生理仪,对78名18~55岁健康成人受试者（男性43名,女性35名）,作PPI测定,并于28天后随机抽取21名受试者重复测试PPI。结果 （1）21名受试者首次测试及28天后测试时PPI波幅及潜伏期比较差异不明显（P〈0.05）;（2）本研究中健康成人PPI数值为61±29%;（3）PPI男女性别比较差异未达显著性（P〉0.05）。结论健康成人PPI可由弱-强刺激结合的被动注意PPI范式诱发,间隔一定时间后仍波形稳定,未发现明显性别差异。Objective To investigate the characteristics of sensory gating（ SG） of healthy adults Chinese by using the method of prepulse inhibition of the startle reflex. Methods The prepulse inhibition（ PPI） of the startlereflex was assessed in 78 healthy adults Chinese（ 43 males,35 females）,aging 18 to 55,by using a Brain Product＇s ERP instruments was used to record. Results 1No significant different was found in 23 healthy adults Chinese 4 weeks after the first assessment. 2Mean values of healthy adults Chinese was obtained（ 61±29%）. 3No gender effect was found in PPI between male and female subjects（ P〈 0. 05）. Conclusion Prepulse inhibition can be elicited by auditory prepulse- pulse paradigm,and PPI was found stable in healthy adults Chinese and no gender difference was found of PPI in Han Chinese.

关 键 词：健康成人 惊跳反射弱刺激抑制 正常值库 

分 类 号：R749.41[医药卫生—神经病学与精神病学]