甲泼尼龙冲击对儿童睡眠中癫痫性电持续状态的治疗效果观察  

Clinical Effect Observation of Methylprednisolone in Treating Children with Electrical Status Epilepticus During Sleep

作　　者：王朋朋[1] 谢鹤[1] 吴淑庄[1] 黄斌[1] 

机构地区：[1]广东省潮州市中心医院儿科,广东潮州521000

出　　处：《临床医学工程》2015年第2期172-173,共2页Clinical Medicine & Engineering

摘　　要：目的探察采用甲泼尼龙冲击治疗儿童睡眠中癫痫性电持续状态(ESES)的临床效果。方法将符合标准的64例ESES患儿随机分为两组各32例。对照组患者采用传统的抗癫痫药物治疗,治疗组患者采用甲泼尼龙冲击治疗。观察两组患者的临床效果及药物的不良反应情况。结果治疗后两组患者病情均有改善,总有效率并无显著差异(P>0.05);两组患儿均出现痫样放电,治疗组的有效率为84.4%,显著高于对照组的56.3%(P<0.05);治疗组患儿用药六个月后的认知能力VIQ、FIQ、PIQ等评分均高于对照组(P<0.05)。结论采用甲泼尼龙冲击治疗儿童ESES,可有效改善患儿的认知能力,缓解患儿的临床症状,治疗效果显著,值得推广。Objective To explore the clinical effect of methylprednisolone in treating children with electrical status epilepticus during sleep（ESES）. Methods 64 ESES children met the standards were randomly divided into two groups. The control group（32 cases） received traditional antiepileptic drug therapy, the treatment group（32 cases） was given methylprednisolone theray. The clinical effect and adverse reactions were observed. Results After treatment, the patients＇ conditions of two groups were improved, but the total effective rate had no statistical difference（P 0.05）; all patients had epileptiform discharge, and the effective rate of treatment group was 84.4%, significantly higher than 56.3% of control group（P 0.05）; the cognitive ability of VIQ, FIQ, PIQ scores after 6 months medications of treatment group were significantly higher than those of control group（P 0.05）. Conclusions Methylprednisolone can effectively improve children＇s cognitive ability and alleviate the clinical symptoms in treating ESES children with significant treatment effect, which deserves promotion.

关 键 词：甲泼尼龙 儿童睡眠中癫痫性电持续状态 临床疗效 

分 类 号：R742.1[医药卫生—神经病学与精神病学]