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机构地区:[1]重庆市石柱土家族自治县人民医院病理科,409100 [2]重庆市石柱土家族自治县人民医院普外科,409100
出 处:《检验医学与临床》2015年第4期454-456,459,共4页Laboratory Medicine and Clinic
基 金:重庆市卫生局医学科研计划项目(2012-2-336)
摘 要:目的探讨肠道腺癌中肺耐药相关蛋白(LRP)、P-糖蛋白(P-gp/P170)、拓扑易构酶(ToPoⅡ)、胸腺嘧啶合成酶(Ts)及谷胱甘肽转移酶(GST)-π的表达水平及其临床意义。方法采用免疫组化法检测96例原发性肠道腺癌及15例正常肠黏膜中Ts、P170、ToPoⅡ、LRP、GST-π的表达情况,并综合分析其与各临床参数和预后的关系。结果 LRP、P170、ToPoⅡ、Ts在肠道腺癌组织中呈高表达状态;5种蛋白在癌组织中的表达水平与年龄、性别无关,但在有淋巴结转移者表达高于无淋巴结转移者,LRP、P170在低分化腺癌组织中的表达明显高于高中分化腺癌,而Ts的表达明显低于高中分化腺癌;浸润肌层及以内的腺癌表达ToPoⅡ明显高于浸润至浆膜者;LRP、P170、Ts阳性表达患者的5年存活率低于阴性表达者。结论 Ts、P170、ToPoⅡ、LRP、GST-π5种耐药蛋白与肠道腺癌分化程度、浸润深度、淋巴结转移以及5年存活率均有不同程度的相关性,这在制订肠道腺癌的个性化化疗方案以及患者预后评估上具有重要的临床意义。Objective To investigate the expression and clinical significance of Thymine synthetase(Ts),Pglycoprotein(P170),toposiomerase(ToPoⅡ),lung resistance-related protein(LRP),glu tathione tfan sferase(GST-π)in colorectal carcinoma tissue.Methods The expression of Ts,P170,ToPoⅡ,LRP and GST-πin 96 patients with colorectal carcinoma and 15 healthy persons were detected by immunohistochemical technique,and their relationship with clinical indicators and prognosis of carcinoma were explored.Results LRP,P170,ToPoⅡ and Ts in in testinal tissues showed high expression in intestinal adenocarcinoma.The five kinds proteins expression levels in the adenocarcinoma had no relationship with age and gender,but these were higher in the cases with lymph node metastasis than those without lymph node metastasis.The levels of LRP,P170 in low differentiation adenocarcinoma were significant higher than that in high differentiation adenocarcinoma,while the expression of Ts was significant lower than that in high differentiation adenocarcinoma.The expression of ToPoⅡ was significant higher in invasion muscle layer than that of infiltrated serosa.The five years survival rate of patients with positive expression of LRP,P170 were lower than that of the negative expression cases.Conclusion Ts,P170,ToPoⅡ,LRP and GST-πhave relationships with intestinal adenocarcinoma differentiation degree,invasion depth,lymph node metastasis and the survival rate of five years,these relationships important for personalized chemotherapy scheme and prognostic evaluation.
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