眼肿瘤眼眶病中常见实验动物模型研究进展  

Progress in the development of common experimental animal models of the eye neoplasm and the orbital diseases

作　　者：李金茹[1] 马建民 

机构地区：[1]首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华实验眼科杂志》2015年第2期184-188,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（81170785）;北京市卫生系统高层次卫生技术人才培养计划项目（2011-3-041）

摘　　要：眼肿瘤眼眶病是一类危害人类视功能,甚至生命的严重疾病.目前多数眼肿瘤眼眶病的病因及发病机制仍未明确,这给其治疗带来了不利影响.医学实验动物模型是利用动物体来研究人类疾病的实验模型.通过建立不同疾病的实验动物模型,不仅有助于了解疾病本身的病因、病理机制,而且可以为其治疗提供研究平台.尽管眼肿瘤眼眶病较眼科其他疾病的动物模型研究较少,但近年来有关眼肿瘤眼眶病动物模型的研究仍然取得了一些进展.就几种常见的眼肿瘤眼眶病相关动物模型,甲状腺相关眼病（TAO）动物模型、眼眶腺样囊性癌动物模型、视网膜母细胞瘤（RB）动物模型、葡萄膜黑色素瘤动物模型、眼眶炎性假瘤动物模型的研究进展进行综述.The eye neoplasm and the orbital diseases are a class of serious illness which will cause visual function damage and even life threatening.At present,the etiology and pathogenesis of the most eye neoplasm and orbital diseases are still not clear,which has an adverse effect on the treatment.The medical experimental animal models are the ideal model to simulate human diseases.At the same time,the establishment of related animal models with the eye neoplasm and the orbital diseases is a helpful aid in getting to know the etiology and pathogenesis,providing a basis for studying the etiology and pathogenesis of these diseases.Some progress has been achieved some progress in recent years,however,compared to other diseases,the related animal models of these are still few.The progress in the common experimental animal models of the eye neoplasm and the orbital diseases,the animal models of the thyroid-associated ophthalmopathy （TAO）,the orbital adenoid cystic carcinoma,the retinoblastoma （RB）,the uveal melanoma,and the idiopathic orbital inflammatory pseudotumor were reviewed in this article.

关 键 词：眼肿瘤 眼眶病 动物模型/实验性 

分 类 号：R739.7[医药卫生—肿瘤] R-332[医药卫生—临床医学]