肿瘤神经新生研究进展  

Research progress on tumor neurogenesis

作　　者：陆伟[1,2] 季彤[1,2] 

机构地区：[1]上海交通大学医学院附属第九人民医院.口腔医学院口腔颌面-头颈肿瘤科 [2]上海市口腔医学研究所,上海200011

出　　处：《中国口腔颌面外科杂志》2015年第1期90-93,共4页China Journal of Oral and Maxillofacial Surgery

基　　金：上海交通大学医工交叉研究基金(YG2011MS58)~~

摘　　要：传统观点认为,肿瘤中不存在新生神经,而近几年出现的有关肿瘤内发现新生神经的报道引起了相关领域内研究者极大的兴趣。他们推测,正常机体内神经往往与血管和淋巴管相伴而行。已有研究证明,肿瘤中存在"新生血管"、"新生淋巴管"、那也应存在"新生神经",而其对肿瘤的作用如何,研究者对其进行了探索。肿瘤中是否有新生神经的存在?两者之间存在怎样的相互作用?机制又如何?本文旨在对目前有关神经和肿瘤的研究成果做一综述。The reason why few studies have been made on ＂neurogenesis in tumors＂ was based on the old-fashioned notion that tumors were not able to induce growth of fresh nerve fibers. However, it now attracts huge interests among researchers as new evidence gradually emerged in recent years. The hypothesis is presented as follows： as we all know,nerve fibers accompany blood vessels and lymphatic vessels all over the human body. Since an extensive amount of knowledge has been obtained with regard to increased angiogenesis and lymph angiogenesis within tumors, chances are that there also exists neurogenesis as well. The mutual relationships and specific functions between new nerve fibers and tumors have also been wildly contemplated by some scholars. This review was intended to discuss the current understanding of this topic and some novel findings.

关 键 词：肿瘤神经新生 肿瘤微环境 神经-肿瘤突触 

分 类 号：R730.2[医药卫生—肿瘤]