附睾乳头状囊腺瘤2例并文献复习  

Papillary cystadeuoma of the epididymis: A report of 2 cases and review of the literature

作　　者：张伟[1] 涂频[1] 王建军[1] 何燕[1] 余波[1] 王海[1] 石群立[1] 

机构地区：[1]南京大学医学院临床学院/南京军区南京总医院病理科,江苏南京210002

出　　处：《中华男科学杂志》2015年第2期157-160,共4页National Journal of Andrology

摘　　要：目的:探讨附睾乳头状囊腺瘤的临床病理学特征。方法:应用常规病理、免疫组化方法观察2例附睾乳头状囊腺瘤手术切除标本,结合相关临床资料及其病理学特点进行分析,并复习相关文献。结果:2例患者均为成年男性。临床表现为阴囊(附睾处)无痛性肿块,或偶有隐痛及下坠感。肿瘤组织学包括3个主要特征:扩张的导管和小囊肿及被覆高柱状上皮、以纤维血管间质为轴心的乳头状增生的腺样结构,囊腔内可见嗜酸性物质。免疫表型:瘤细胞表达CK8/18、CK7、EMA;而CK20、CEA、MC、Calretinin、P53、P63、SMA、VHL和CD10均阴性,Ki67<1%阳性。随访:2例患者预后良好。结论:附睾乳头状囊腺瘤是泌尿生殖系统少见的良性肿瘤,可伴有VHL综合征。手术是治疗该肿瘤的首选方法。Objective ： To study the clinicopathological characteristics of papillary cystadenoma of the epididymis. Methods ： Using routine pathology and immunohistochemistry, we observed the surgically obtained samples from 2 cases of papillary cystadenoma of the epididymis, analyzed their pathological features and clinical presentations, and reviewed the related literature. Results： The 2 patients were both adult males. The tumors typically manifested as painless swelling in the epididymis, with occasionally dull pain and tenesmus in 1 of the cases. Pathologically, the lesions exhibited three morphological features, i. e. , dilated ducts and small cysts sur- rounded by fibrous connective tissue, adenoid papillary hyperplasia into the cysts embraced by fibrovascular stroma, and acidophil sub- stance present in the cysts. Immunohistochemistry showed that the tumors were strongly positive for CK8/18, CKT, and EMA, but neg- ative for CK20, CEA, MC, Calretenin, P53, P63, SMA, VHL, and CD10, with the positive rate of Ki-67 〈 1%. Follow-up visits revealed good prognosis in both cases. Conclusion ： Papillary cystadenoma of the epididymis is a rare benign tumor in the male urogeni- tal system, which may be accompanied by the VHL syndrome. Surgery is the first choice for its treatment.

关 键 词：附睾 乳头状囊腺瘤 鉴别诊断 

分 类 号：R737.21[医药卫生—肿瘤]