前列腺癌肿瘤干细胞的研究进展  

Prostate cancer stem cells: Advances in current research

作　　者：吴刚[1] 吴登龙[1] 

机构地区：[1]同济大学附属同济医院泌尿外科,上海200065

出　　处：《中华男科学杂志》2015年第2期170-174,共5页National Journal of Andrology

基　　金：国家自然科学基金(81172426);上海市教委创新重点项目(12ZZ034)~~

摘　　要：前列腺癌是严重威胁男性健康的恶性肿瘤,其发生发展机制仍未完全阐明。近十年来,前列腺癌肿瘤干细胞的研究取得了诸多进展。前列腺癌肿瘤干细胞被认为可能是前列腺癌的细胞起源,并在肿瘤发生、复发、转移、去势抵抗及耐药等多个方面发挥作用。因此,对前列腺癌肿瘤干细胞的深入研究对彻底治疗前列腺癌具有重要意义。本文从肿瘤干细胞的角度就前列腺癌肿瘤干细胞的位置、细胞起源、表面标志物及其与肿瘤转移、去势抵抗的关系等作一综述。Prostate cancer is one of the most common malignancies threatening men~ health, and the mechanisms underlying its initiation and progression are poorly understood. Last decade has witnessed encouraging progress in the studies of prostate cancer stem cells （PCSCs） , which are considered to play important roles in tumor initiation, recurrence and metastasis, castration resistance, and drug resistance. Therefore, a deeper insight into PCSCs is of great significance for the successful management of prostate cancer. This article presents an overview on the location, origin, and markers of PCSCs as well as their potential correlation with tumor metastasis and castration resistance.

关 键 词：前列腺癌 肿瘤干细胞 细胞标志物 去势抵抗 

分 类 号：R737.25[医药卫生—肿瘤]