黄连素联合阿托伐他汀对急性缺血性卒中患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白水平的影响  

Influence of berberine combining with atorvastatin on serum high-sensitivity Creactive protein and adipocyte fatty acid-binding protein in patients with acute ischemic stroke

作　　者：朱飞奇[1] 陈略[2] 朱瑾华[1] 

机构地区：[1]汕头大学医学院附属粤北人民医院神经内科,韶关512025 [2]广东省佛山市顺德区第一人民医院神经内科,528300

出　　处：《中国现代神经疾病杂志》2015年第1期43-47,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：广东省教育厅大学生创新创业训练项目(项目编号:1056012110);2011年度广东省韶关市科技计划项目[项目编号:韶科(卫)2011-17]~~

摘　　要：目的观察黄连素联合阿托伐他汀对急性缺血性卒中患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平的影响,评价其临床疗效。方法 55例急性缺血性卒中患者随机分为阿托伐他汀20 mg/d组、阿托伐他汀40 mg/d组和黄连素0.40 g(3次/d)+阿托伐他汀20 mg/d组(联合治疗组),治疗3个月后比较血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达变化。结果治疗前后3组患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平差异均有统计学意义(P=0.023,0.000);治疗后3个月时,3组患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平不同程度下降,分别为(1.69±2.29)和(281.43±311.05)mg/L、(7.81±12.48)和(321.59±289.35)mg/L、(2.16±3.34)和(376.55±249.72)mg/L,但组间差异未达到统计学意义(均P>0.05),而且治疗药物与观察时间点之间不存在交互作用(均P>0.05)。结论黄连素联合阿托伐他汀降低急性缺血性卒中患者血清炎症反应标志物超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平的作用与阿托伐他汀强化治疗(40 mg/d)相似。Objective To observe the influence of berberine combining with atorvastatin on serumhigh-sensitivity C-reactive protein（hs-CRP） and adipocyte fatty acid-binding protein（A-FABP） in patientswith acute ischemic stroke.Methods Ischemic stroke patients（N = 55） were randomized into 3 groups：atorvastatin 20 mg/d（N = 28）, atorvastatin 40 mg/d（N = 11） and berberine 0.40 g three times a day ＋atorvastatin 20 mg/d（combined treatment, N = 16）. They were treated for 3 months. The expression changes of serum hs- CRP and A- FABP before and after treatment were compared among 3 groups.Results There were significant decreases between before and 3 months after treatment on the expressionof hs-CRP and A-FABP in 3 groups（P = 0.023, 0.000）. After treatment, both the expression of hs-CRP andA- FABP significantly decreased, and the decreases were（1.69 ± 2.29） and（281.43 ± 311.05） mg/L inatorvastatin 20 mg/d group,（7.81 ± 12.48） and（321.59 ± 289.35） mg/L in atorvastatin 40 mg/d group, and（2.16 ± 3.34） and（376.55 ± 249.72） mg/L in combined treatment group. However, there was no significant difference amPong 3 groups（P〉 0.05, for all）, and there was no correlation between drugs and observationtime points（P〉 0.05, for all）.Conclusions The effect of berberine combined with atorvastatin on hs-CRPand A-FABP is similar to atorvastation（40 mg/d） therapy.

关 键 词：脑缺血 小檗碱 降血脂药 C反应蛋白质 脂肪酸结合蛋白质类 

分 类 号：R743.3[医药卫生—神经病学与精神病学]