透明颤菌血红蛋白的结构功能和应用进展  

The Structure-function Relationship of Vitreoscilla Haemoglobin and Its Application in Biotechnology

作　　者：陈云美 徐海洋[1] 王世明[1] 

机构地区：[1]南京理工大学分子代谢中心,南京210094

出　　处：《生物技术通报》2015年第2期53-60,共8页Biotechnology Bulletin

基　　金：中央高校基本科研业务费专项资金(30920130121013)

摘　　要：透明颤菌血红蛋白(VHb)是科学家发现的第一种微生物血红蛋白,它的结构、生化功能以及表达调控机制都已经得到广泛的研究。VHb可以在很多宿主细胞中表达,通过促进氧的输送增强呼吸和能量代谢,以提高许多有用的代谢产物(抗生素、蛋白质、聚合物等)的产量和宿主抗逆性,还能降低有害化合物的毒害。重点从VHb的功能与结构、在提高微生物代谢产物的产量,以及对动植物某些特性的影响和增加生物修复能力等方面的应用进展进行了综述,并对VHb在植物代谢和动物代谢中具有很大的发展空间进行了展望。The hemoglobin from the bacteriumVitreoscilla（VHb）is the firstmicrobial hemoglobin, which has been extensively studied with respect to its structure, biochemical functions, and the mechanisms by which itsexpression is controlled. Expressing VHb in a variety of heterologous hostsresults substantial increasesin production of a variety of useful products（antibiotics, proteins, polymersetc.）, host resistance andability to degrade some harmful compounds, by promoting oxygen transport to enhance respiratory and energy metabolism. So this paper reviewed on the function and structure of VHb and the improving output of microbial metabolites, some characteristics of plants and animals and influence of the application of bioremediation capability. And we discussed about the application prospect and development space in the metabolism of plant and animal.

关 键 词：透明颤菌血红蛋白 生物制剂 代谢产物 生物修复 发酵工程 

分 类 号：Q51[生物学—生物化学]