攻癌镇痛散外敷治疗癌性疼痛的临床研究  

Cli nical Observation on 94 Cases of Gongaizhengtong Powder for External Application on Cancer Pain

作　　者：巫桁锞[1] 蒋参[1] 蒋唯 熊慧生[1] 

机构地区：[1]重庆市肿瘤研究所,重庆400030 [2]重庆市沙坪坝区第二人民医院,重庆400030

出　　处：《中国中医急症》2015年第2期215-216,268,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：重庆市卫生局中医药科技项目(2011-2-25)

摘　　要：目的观察攻癌镇痛散外敷治疗癌性疼痛的临床疗效。方法将94例肿瘤伴癌性疼痛患者均予基础治疗,随机分为中药组、西药组各30例(分别予攻癌镇痛散外敷,西药三阶梯止痛疗法),中西医结合组34例(予上述中西药合用),观察肿瘤患者止痛效果、生活质量改善情况及不良反应。结果总有效率比较,中药组66.67%,低于西药组的93.33%及中西医结合组的94.12%(P<0.05);西药组和中西医结合组疗效相近(P>0.05)。起效时间、疗效持续时间比较,中药组低于西药组及中西医结合组(P<0.05);西药组和中西医结合组疗效相近(P>0.05)。KPS评分比较,中药组的改善不及西药组和中西医结合组(P<0.05);西药组和中西医结合组治疗后KPS评分均改善效果相近(P>0.05)。不良反应发生率比较,中药组为16.67%,低于西药组的90.00%及中西医结合组的52.94%(P<0.05);西药组和中西医结合组发生相近(P<0.05)。结论攻癌镇痛散外敷与三阶梯止痛疗法结合治疗癌性疼痛疗效显著,可明显改善生活质量,明显降低患者应用三阶梯药物的主要不良反应。Objective： To observe the analgesic effect of Gongaizhengtong Powder for external application on cancer pain. Methods： 94 cases were randomly divided into the group of western medicine treatment（W group）,chinese medicine treatment（C group） and integrated traditional and western medicine treatment（CW group）,30 cases in W group with the 3 step therapy, 30 cases in C group with external application of Gongaizhengtong Powder,34 cases in CW group with both of the treatment methods above.Some indices were observed including the antalgic effect,the life quality moprovement and the adverse reaction. Results： The study showed that analgesic effects of W group and CW group were significantly better than C group（Effective Rate 93.33% 94.12% vs.66.67%,P 〈0.05）. In the compare of subgroups, effective rate in CW group was slightly higher than that in W group（94.12% vs. 93.33%）, but the difference was not statistically significant（P 〉0.05）. Similarly, there was a faster onset time, longer duration of analgesic effect and better quality of life in W group and CW group with those in C group（P 〈0.05）. But, in the compare of subgroups, the onset time, duration and quality of life were no difference between W group and CW group（P 〉0.05）. While C group significantly reduced adverse reaction rate compared with W group or CW group（P 〈0.05）,and in the compare of subgroups, The study also showed that the rate of adverse reaction was lower in CW group than that in W group（P 〈0.05）. Conclusions： The study showed that combined use of Gongaizhengtong Powder for external application and western medicine can synergistically enhance the analgesic effect, improve the quality of life, and significantly reduce adverse reactions.

关 键 词：癌性疼痛 攻癌镇痛散 中药外敷 外治法 恶性肿瘤并发症 

分 类 号：R730.59[医药卫生—肿瘤]