路优泰治疗卒中后抑郁的临床疗效研究  

Clinical Effect of Neurostan on Post-stroke Depression

作　　者：邱继红[1] 牟元云[1] 

机构地区：[1]重庆市精神卫生中心,401147

出　　处：《临床合理用药杂志》2015年第3期21-22,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨路优泰治疗卒中后抑郁的临床疗效。方法选取2013年6月—2014年6月于重庆市精神卫生中心就诊的卒中后抑郁患者52例,随机分为两组,路优泰组27例,丙咪嗪组25例。路优泰组采用路优泰治疗,丙咪嗪组采用丙咪嗪治疗,治疗时间为8周。在治疗前和治疗后2、4、8周分别采用汉密顿抑郁评定量表(HAMD)、副反应量表(TESS)对两组患者进行评定。结果路优泰组总有效率为70.4%,丙咪嗪组为72.0%,两组差异无统计学意义(P>0.05)。路优泰组治疗1、2、4、8周末TESS评分比丙咪嗪组低,差异有统计学意义(P<0.05)。结论路优泰治疗卒中后抑郁安全、有效。Objective To explore the clinical effect of neurostan on post-stroke depression. Methods A total of52 patients with post-stroke depression were selected in Chongqing Mental Health Center from June 2013 to June 2014,and they were randomly divided into neurostan group（ n = 27） and imipramine group（ n = 25）. Patients of neurostan group were treated with neurostan,while patients of imipramine group were treated with imipramine,both groups treat for 8 weeks. Hamilton Depression Rating Scale（ HAMD）,Side Effects Scale（ TESS） accessmet were carried out before treatment and 2,8 weeks after treatment. Results The total effective rate of neurostan group was 70. 4%,that of imipramine group was 72. 0%,the difference was not significantly different（ P 〉0. 05）. TESS score of neurostan group was lower than that of imipramine group at1,2,4,8 weekend of treatment, respectively, the differences were statistically significant（ P 〈0. 05）. Conclusion Neurostan is safe,effective in treating post-stroke depression.

关 键 词：卒中 抑郁症 路优泰 丙咪嗪 治疗结果 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R749.42[医药卫生—临床医学]