帕利哌酮缓释片联合银杏叶提取物治疗精神分裂症临床观察  

Clinical observation of paliperidone extend-release tables combined with ginkgo biloga extract in the treatment of schizophrenia

作　　者：方永修 

机构地区：[1]上海市崇明县精神卫生中心,202150

出　　处：《临床合理用药杂志》2015年第4期20-21,23,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察帕利哌酮缓释片联合银杏叶提取物治疗精神分裂症的临床效果。方法将77例精神分裂患者随机分为治疗组40例和对照组37例。治疗组给予察帕利哌酮缓释片联合银杏叶提取物治疗,对照组给予察帕利哌酮缓释片治疗,疗程6周。用简明精神病评定量表(BPRS)在治疗前及治疗1、2、4、6周末评定疗效,用副反应量表(TESS)评定不良反应。结果治疗第6周末,治疗组的痊愈率为62.5%(25/40)高于对照组的35.1%(13/37),差异有统计学意义(P<0.05)。治疗前2组BPRS评分比较差异无统计学意义(P>0.05),治疗组的BPRS的评分从第1周末起明显下降(P<0.05),且一直持续到治疗第6周末;而对照组的BPRS评分从第2周末才开始明显下降(P<0.01);治疗第1、2周末,治疗组的BPRS的评分比对照组下降明显(P<0.01),但在第4、6周,2组BPRS的评分下降差异无统计学意义(P>0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。2组TESS评分差异无统计学意义(P>0.05)。结论帕利哌酮缓释片合并银杏叶提取物治疗精神分裂症比单用帕利哌酮缓释片起效更快,但2周后BPRS减分率的差异无统计学意义,可以不必继续联合使用银杏叶提取物。Objective To observe the clinical effect of paliperidone extend-release tables combined with ginkgo biloga extract in the treatment of schizophrenia. Methods 77 patients with schizophrenia were randomly divided into treatment group （40 cases） and control group （37cases）. The treatment group was treated with paliperidone extend-release tables combined with ginkgo biloga extract, and control group was treated with paliperidone extend-release tables only. Then evaluated the cura- tive effect by the brief psy-chiatric rating scale （BPRS） 1,2,4,6 weeks after treatment, and evaluate adverse reaction by treat- ment emergent symptom scale（TESS）. Results After six weeks＇ treatment,the curative rate of treatment group was 62.5% （ 25/40 ） was higher than that of the control group 35.1% （ 13/37 ）, the difference was statistically significant （ P 〈 0.05 ）. Be- fore the treatment, there was no significant difference in BPRS score of the two groups （ P 〉 0.05 ）. The treatment group of BPRS score from the first weekend decreased significantly （ P 〈 0.05 ） , and continued until sixth week. While in the control group, BPRS score from the second weekend began to decline significantly（P 〈 0.01 ）. The BPRS score of treatment group was significantly lower than that of control group during the first and second weeks （ P 〈 0.01 ）, but during forth and sixth weeks, the decrease of BPRS score between the two groups had no significant difference（ P 〉 0.05 ）. The incidence of adverse reactions of 2 groups has no statistically signific ant（ P 〉 0.05 ）. The adverse reaction rates and TESS score between the two groupswere not statistically significant （ P 〉 0.05 ）. Conclusion The paliperidone extend-release tables combined with ginkgo biloga extract in the treatment of schizophrenia takes effect faster than using paliperidone extend-release tables only, however, the reduced rate of BPRS was no significant difference. But after 2 weeks, it is unnecessary to use ginkgo bil

关 键 词：银杏叶提取物 精神分裂症 帕利哌酮缓释片 简明精神病评定量表 副反应量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]