CD68^+、CD163^+巨噬细胞对食管癌浸润及预后的影响  

Influence of CD68^+ and CD163^+ macrophages on the infiltration of esophageal carcinoma and its prognosis

作　　者：张志斌[1] 朱艳[1] 席俊峰[1] 

机构地区：[1]陕西省榆林市第一医院,陕西榆林719000

出　　处：《现代中西医结合杂志》2015年第6期590-592,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨CD68+、CD163+巨噬细胞对食管癌浸润及预后的影响。方法收集手术切除的食管癌组织标本84例、食管癌旁组织标本49例,采用免疫组化法检测组织标本中CD68+、CD163+巨噬细胞浸润密度,并对患者预后进行分析。结果食管癌组织中CD68+、CD163+巨噬细胞浸润密度每视野(35.69±14.50)个和(29.78±12.36)个,中位数分别为32.8个和27.1个;癌旁正常组织中CD68+、CD163+巨噬细胞浸润密度每视野(4.26±2.30)个和(2.33±1.71)个,中位数分别为3.4个和2.2个。食管癌组织中CD68+、CD163+巨噬细胞浸润密度明显高于癌旁正常组织(P均<0.05)。TNMⅢ期者、有淋巴结转移者、低分化程度者CD68+、CD163+巨噬细胞浸润密度明显高于TNMⅠ~Ⅱ期者、无淋巴结转移者、高中分化程度者(P均<0.05);患者术后1年、3年、5年生存率分别为83%,67%,46%,中位生存时间为44.21个月。Spearman相关分析显示,CD68+、CD163+巨噬细胞浸润密度与患者生存时间呈现负相关性(P<0.05);多因素Cox回归分析TNM分期、淋巴结转移、分化程度、CD163+巨噬细胞浸润密度是影响患者预后的独立危险因素(P均<0.05)。结论食管癌患者局部病灶组织中CD68+、CD163+巨噬细胞浸润密度明显增高,CD163+巨噬细胞浸润密度增高是影响患者预后的独立因素。Objective It is to approach the influence of CD68^＋, CD163^＋ macrophage on the infiltration of esophageal cancer and its prognosis. Methods 83, cases of specimens of esophageal carcinoma in resection operation and 49 cases of e-sophageal paracancerous tissues were collected, the infiltration density of CD68^＋ , CD163^＋ macrophage in the specimens were detected by immunohistochemistry method, and the prognosis of the patients were analyzed. Results The every field mean den- sity of CD68^＋ , CD163^＋ macrophages infiltrating in esophageal cancer tissue was 35.69 ± 14.50 and 29.78 ± 12.36 respec- tively, the median was 32.8 and 27.1. The results in paracancerous tissues was 4.26 ± 2.30 and 2.33 ± 1.71, the median was 3.4 and 2.2 respectively, the median was 32.8 and 27.1. The infiltration density of CD68 ^＋ and CD163^＋ macrophage in esophageal cancer tissue was significantly higher than that in paracancerous tissues （ all P 〈 0.05 ）. The infiltration density of CD68^＋, CD163^＋ macrophage with TNM m stages, lymph node metastasis, or low differentiation degree, was significantly higher than that with TNM stage I to Ⅱ , without lymph node metastasis, and high differentiation degree （ all P 〈 0.05）. The survival rates after operation of 1 year, 3 years, 5 years were 83% , 67% and 46% , the median survival time was 44.21 months. Spearman correlation analysis showed that there was negative correlation between the infiltration density of CD68^＋ , CD163^＋ macrophage and the survival time of patients （P 〈 0.05） ; multivariate Cox regression analysis showed that the TNM stage, lymph node metastasis, differentiation, CD163^＋ macrophage infiltration density affects the prognosis of patients with in- dependent risk factors （ all P 〈 0.05）. Conclusion The CD68^＋ , CD163^＋ macrophage infiltration density in local lesion tis- sue of patients with esophageal cancer are increased significantly, the increase of CD163^＋ macrophages infiltration density is an independent facto

关 键 词：食管癌 CD68^+巨噬细胞 CD163^+巨噬细胞 浸润 预后 

分 类 号：R735.1[医药卫生—肿瘤]