不同生长方式的鼻咽癌侵犯颅底对肿瘤复发转移的影响  

Correlation among different structure erosion with recurrence and metastasis in nasopharyngeal carcinoma

作　　者：刘琦[1] 赖庆君 朱介宾[1] 张纯[1] 贾筠[1] 

机构地区：[1]东莞市人民医院肿瘤内科,广东523000

出　　处：《齐齐哈尔医学院学报》2015年第4期490-492,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨不同生长方式的鼻咽癌侵犯颅底的临床特点和对复发转移的影响。方法2009—2013年我院住院治疗的143名鼻咽癌并颅底受侵患者,通过磁共振检查(MRI)和病历进行回顾性分析。不同肿瘤生长方式侵犯颅底之间的比较采用四表格卡方检验。结果鼻咽癌侵犯颅底有五种生长类型,肿瘤向上生长者与其它类型相比较,肿瘤分期较早,两组间有统计学意义(P=0.001<0.01),同时,向上生长组初治时发生远处转移也较其他类型为少,两组有统计学差异(P=0.015<0.05)。治疗后各组间肿瘤复发没有统计学差异(P=0.290>0.05),但是与其他组相比,治疗后向上生长组远处转移发生较少,有统计学差异(P=0.013<0.05)。结论向上生长肿瘤侵犯颅底患者的临床分期相对较早,远处转移发生概率较小。Objective To study the clinical characteristics of skull base erosion, analyze the correlation among different structure erosion with recurrence or metastasis in nasopharyngeal carcinoma（NPC）. Methods A total of 143 patients who were diagnosed with NPC between 2009 and 2013 were included in this study. MRI images and medical records were analyzed retrospectively. Difference between skull base erosion was analyzed using the X2 test. Results The bone destruction of the skull base were divided into five types. Before therapy, up-grown skull base erosion has less advanced TNM stage （P = 0. 001 〈 0. 01 ） and less metastasis than other types （P = 0. 015 〈 0. 05 ）. After therapy, among the different group, the recurrence of NPG are similar （ P = 0. 290 〉 0. 05 ）. But up-grown skull base erosion has less metastasis （ P = 0. 013 〈 0. 05 ）. Conclusions Compared to other types, up-grown skull base erosion has less advanced TNM stage and less metastasis.

关 键 词：肿瘤生长方式 侵犯颅底 复发转移 鼻咽癌 统计学差异 住院治疗 远处转移 磁共振检查 

分 类 号：R739.630.4[医药卫生—肿瘤]