原发乳腺癌前哨淋巴结阳性患者非前哨淋巴结转移的预测因子  

Predictors for non-sentinel lymphnode metastases in breast cancer patients with positive sentinel lymphnodes

作　　者：黄晖[1] 顾然[2] 陈凯[2] 苏逢锡[2] 李顺荣[2] 金亮[2] 吴建南[2] 邓贺然[2] 许焕玲[1] 岑红艺[1] 

机构地区：[1]江门市妇幼保健院乳腺外科,广东江门529030 [2]中山大学附属孙逸仙纪念医院乳腺中心,广州2510120

出　　处：《岭南现代临床外科》2015年第1期10-16,共7页Lingnan Modern Clinics in Surgery

基　　金：广东省医学科研基金(B2013386);国家自然科学基金(81372817)

摘　　要：目的分析前哨淋巴结(SLN)阳性原发乳腺癌患者腋窝非前哨淋巴结(NSLN)转移的预测因子。方法回顾性分析212例SLN阳性并接受腋窝淋巴结清扫术的患者资料。获取的SLN均按示踪剂浓度排序并测量浸润灶大小。对各种临床及病理组织学因素数据进行单因素分析,纳入单因素分析有意义(P<0.05)的预测因素进行logistic多因素分析。结果多因素分析提示NSLN转移与SLN转移率(P<0.001)、SLN阴性个数(P=0.02)、染色剂浓度最小SLN转移(P=0.02)、SLN最大转移灶大小(P<0.001)有关。全部SLN转移者NSLN转移可能性较非全部SLN转移者大;随SLN阴性个数增加,NSLN转移率下降;染色剂浓度越大SLN转移机会越大,浓度最小SLN转移者较浓度最小SLN无转移者SLN,其NSLN转移几率更高;最大转移灶>2 mm者出现NSLN转移可能性比SLN最大转移灶≤2 mm者大。结论 SLN转移率(P<0.001)、SLN阴性个数(P=0.02)、染色剂浓度最小SLN转移(P=0.02)、SLN最大转移灶大小(P<0.001)是NSLN转移的独立预测因子。Objective To investigate the predictable factors of metastasis in non sentinel lymph nodes（NSLN） in patients with prime breast cancer with positive sentinel lymph nodes（SLN）.Methods Patients with primary breast cancer and positive sentinel lymph node（n=212） were included in this retrospective study.All patients had positive SLNs that had been ordered by the concentration of tracer,and were analyzed to determine factors that predicted additional positive axillary nodes. Pearson Chi-square or T-test were used for univariate analysis. Logistic regression was used for multivariate analysis..Results Of 212 breast cancer patients with positive sentinel lymph node ranked by the concentration of tracer, multivariate analysis revealed that NSLN was associated with the SLN metastases rate（P〈0.001）, the number of negative SLN（P=0.02）, metastases in the latest lymph node（P =0.02） and the size of SLN metastases（P 0.001） which independently predicted the NSLN metastases. Conclusion SLNs with higher concentration of tracer might have higher possibility of metastasis. Our study suggested that the SLN metastases rate, the number of negative SLN, metastases in the latest lymph node and the size of SLN metastases independently associated with NSLN metastasis.

关 键 词：原发乳腺癌 前哨淋巴结活检术 非前哨淋巴结转移 预测因子 

分 类 号：R737.9[医药卫生—肿瘤]