CREB和CXCR2在非小细胞肺癌组织中的表达及意义(英文)  

The Expression and Significance of CREB and CXCR2 in NSCLC

作　　者：石瑞雪[1] 吕坤聚[1] 张柯晴 高伟[1] 

机构地区：[1]中国人民解放军第401医院呼吸内科,山东青岛266000

出　　处：《现代生物医学进展》2014年第34期6714-6718,共5页Progress in Modern Biomedicine

基　　金：The army scientific research subjec(t06Z013)~~

摘　　要：目的:探讨c AMP反应原件结合蛋白(cyclic AMP response element-binding protein,CREB)和CXC趋化因子受体2(CXC chemokine receptor 2,CXCR2)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及与肺癌发生、发展的关系。方法:采用免疫组化Elivision法检测CREB和CXCR2在49例NSCLC组织中的表达,同时随机选取20例癌旁正常肺组织作为对照。结果:NSCLC中CREB和CXCR2的表达阳性率分别为57.1%和69.4%,均显著高于癌旁正常组织中的10.0%和15.0%(P<0.05);同时,CREB和CXCR2在NSCLC组织中的表达不仅与肿瘤的TNM分期有关(P<0.05),而且还与肿瘤的分化程度有关(P<0.05);另外,CREB在吸烟患者中的表达明显高于非吸烟患者(P<0.05),在鳞癌组织中的表达明显高于腺癌(P<0.05);CREB和CXCR2的表达呈正相关。结论:CREB和CXCR2可能参与了NSCLC的发生和发展,为NSCLC的靶向治疗提供了新的依据。Objective： To investigate the protein expression of cyclic AMP response element-binding protein（CREB） and CXC chemokine receptor 2（CXCR2） in non-small cell lung cancer（NSCLC） in order to investigate their relationship with clinical and pathological features of NSCLC patients. Methods： The immunohistochemical Elivision method was used to detect the expression of CREB and CXCR2 in NSCLC tissue（n=49） and adjacent normal lung tissue（n=20）. Results： High expression of CREB and CXCR2 was observed in 57.1 % and 69.4 % of NSCLC tissue and 10 % and 15 % of adjacent normal lung tissue（P0.05）. The expression of CREB and CXCR2 was related to both tumor stages and cell differentiation in NSCLC（P 0.05）. CREB expression was obviously higher in both squamous cell carcinoma and the smokings than that in adenocarcinoma and non-smokings（P 0.05）, whereas CXCR2 in both histologic subtype and Smoking status was less or not affected by them（P 0.05）. CREB expression was demonstrated to associate positively with CXCR2. Conclusion： CREB and CXCR2 may play a vital synergetic role in the progress of NSCLC because of overexpression in NSCLC tissue, which may provide a potential therapeutic target for the prevention and treatment of NSCLC.

关 键 词：肺肿瘤 CREB CXCR2 免疫组织化学 趋化因子 

分 类 号：R734.2[医药卫生—肿瘤]