产后与非产后抑郁症患者事件相关电位P300的对比研究  

Comparative Study on the Event-related Potential P300 between Postpartum and Non Postpartum Depression

作　　者：唐英[1] 陈玖[2] 黄平[1] 杨来启[2] 吴兴曲[2] 

机构地区：[1]成都市新都区妇幼保健院妇产科 [2]解放军第三医院全军精神疾病防治中心

出　　处：《现代生物医学进展》2014年第33期6570-6572,共3页Progress in Modern Biomedicine

基　　金：军队中医药科研专项课题(10ZYX108)

摘　　要：目的：探讨产后抑郁症与非产后抑郁症患者事件相关电位P300的差异,为产后抑郁症的预防提供参考指标。方法：选择2011年1月～2012年10月解放军第三医院精神科收治的35例产后抑郁症患者（产后组）和36例非产后抑郁症患者（非产后组）为研究对象,并检测其事件相关电位P300,并与36名健康志愿者（对照组）的结果进行比较。结果：（1）与对照组相比,产后组、非产后组P2、N2、P3潜伏期均显著延迟,P2、N2、P3波幅均明显降低,差异均有统计学意义（P〈0.05）。（2）与产后组相比,非产后组P2、N2、P3潜伏期差异均无统计学意义（P〉0.05）。P2、N2波幅均偏高,差异均有统计学意义（P2[（5.0±2.1）ms vs.（3.9±1.8）μV],N2[（3.2±1.7）μV vs.（2.1±1.0）μV],P〈0.05）,P3波幅差异无统计学意义（P〉0.05）。结论：产后与非产后抑郁症患者认知功能均受损,非产后抑郁患者受损程度大于产后抑郁患者;产后抑郁的外界感知能力和早期注意受损程度大于非产后抑郁患者。Objective： To explore the difference of event-related potential P300 between postpartum and non postpartum depression, and provide susceptible index for the prevention of postpartum depression. Methods： 35 cases of postpartum depression（postpartum depression group） and 36 cases of non postpartum depressions（non postpartum depression group） hospitalized in the Third Hospital of PLA from January 2011 to October 2012 were selected, event-related potentials P300 were tested and compared with 36 cases of healthy subjects（control group）. Results：（1） Compared with the control group, the postpartum depression group and non postpartum depression group had significant longer latency periods and lower amplitudes of P2, N2, P3（P〈0.05）.（2） Compared with the postpartum depression group, no statistical difference of the latency periods of P2, N2, P3 was found in the non postpartum depression group（P〉0.05）;the amplitudes of P2, N2 were lower in the non postpartum depression group（P2 [（5.0 ±2.1） ms vs.（3.9 ±1.8） μV], N2 [（3.2 ±1.7）μV vs.（2.1 ±1.0） μV], P〈0.05）, and no statistical difference of the amplitude of P3 was found in the non postpartum depression group（P〉0.05）. Conclusion： Both postpartum and non postpartum depression presented a defect on the cognitive function, and the extent of damage in the non postpartum depression was worse than those in the postpartum depression. The extent of external perception and early attention damage in the postpartum depression was worse than those in the non postpartum depression.

关 键 词：产后抑郁症 事件相关电位 P300 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R714.6[医药卫生—临床医学]