食管癌危险饮食因素的Meta分析  被引量:37

The risk dietary factors of esophageal carcinoma: a Meta-analysis

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作  者:冉进军 韩乐飞[1] 杨晓妍[2] 齐鸿超 杨帆[1] 廖欣怡 刘巧兰[1] 

机构地区:[1]四川大学华西公共卫生学院,四川省成都610041 [2]四川大学华西医院华西临床医学院

出  处:《中国慢性病预防与控制》2014年第6期644-647,共4页Chinese Journal of Prevention and Control of Chronic Diseases

基  金:国家自然科学基金资助项目(81102206)

摘  要:目的综合评价各种危险饮食因素在食管癌发病中的影响,为食管癌的有效预防提供依据。方法根据Meta分析的步骤,制定文献检索策略,确定文献纳入和排除标准,并选择固定效应模型或随机效应模型,对近10年间有关中国人群食管癌危险饮食因素的研究结果进行定量综合分析。结果共纳入国内2004-2013年公开发表的23篇文献,累计病例5 269例,对照6 896例,饮酒OR值为1.550(95%CI:1.342-1.758),热烫饮食OR值为1.931(95%CI:1.646-2.217),腌制饮食OR值为1.462(95%CI:1.207-1.716),辛辣饮食OR值为1.523(95%CI:1.146-1.900),油炸饮食OR值为1.574(95%CI:1.228-1.921),高盐饮食OR值为1.547(95%CI:1.305-1.789),霉变饮食OR值为1.564(95%CI:1.347-1.781),硬质饮食OR值为2.107(95%CI:1.169-3.044),快速进食OR值为1.917(95%CI:1.623-2.212),不规律饮食OR值为1.779(95%CI:1.296-2.262)。结论饮酒、热烫饮食、腌制饮食、辛辣饮食、油炸饮食、高盐饮食、霉变饮食、硬质饮食、快速进食和不规律饮食均为食管癌发生的危险饮食因素。Objective To evaluate the role of some risk dietary factors in the incidence of esophageal carcinoma by Meta-analysis and to provide the base for prevention of esophageal carcinoma. Methods According to the Meta analysis steps, literature retrieval strategy was conducted and then inclusion and exclusion criteria were determined. Also fixed effect model and random effect model were selected based on heterogeneity test. The risk dietary factors of esophageal carcinoma in Chinese population from 2004 to2013 were analyzed comprehensively. Results Twenty three articles published from 2004-2013 were included, which contained5 269 cases and 6 896 controls. The pooled odds ratio(OR) values of alcohol drinking, over-hot diet, pickled diet, spicy foods,fried foods, high salt diet, moldy and spoiled foods, hard-food diet, fast-eating diet and irregular diet were 1.550(95%CI: 1.342-1.758), 1.931(95%CI: 1.646-2.217), 1.462(95%CI: 1.207-1.716), 1.523(95%CI: 1.146-1.900), 1.574(95%CI: 1.228-1.921), 1.547(95%CI: 1.305-1.789), 1.564(95%CI: 1.347-1.781), 2.107(1.169-3.044), 1.917(95% CI: 1.623-2.212) and1.779(95%CI: 1.296-2.262), respectively. Conclusion The alcohol drinking, over-hot diet, pickled diet, spicy foods, fried foods,high salt diet, moldy and spoiled foods, hard-food diet, fast-eating diet and irregular diet are the risk dietary factors of esophageal carcinoma.

关 键 词:食管癌 饮食 危险因素 META分析 

分 类 号:R735.1[医药卫生—肿瘤]

 

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