血清视锥蛋白样蛋白-1及其他因素与缺血性卒中后认知障碍的相关性  

Relationship between the serum visinin-like protein-1 level or other factors and cognitive impairment in patients with ischemic stroke

作　　者：李斌[1] 安中平[2] 朱延霞[1] 王涛[1] 

机构地区：[1]大港油田总医院神经内科,天津300280 [2]天津市环湖医院神经内科

出　　处：《中国慢性病预防与控制》2014年第6期687-690,共4页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨血清视锥蛋白样蛋白-1(VILIP-1)浓度及其他因素与缺血性卒中患者认知障碍的关系,为防治或延缓卒中后认知障碍的发生提供科学依据。方法收集2012年6月1日至12月31日在我院神经内科卒中单元住院治疗的急性脑梗死患者124例作为脑梗死组,年龄和性别与其匹配的96例健康志愿者作为正常对照组。根据蒙特利尔认知评估量表评分结果将脑梗死患者分为认知功能障碍组(51例)和认知功能正常组(73例)。收集调查对象的病史和生活习惯资料,对血清VILIP-1、血脂、同型半胱氨酸、超敏C反应蛋白水平进行测定。对各组血清VILIP-1浓度进行比较,分析血清VILIP-1浓度及其他危险因素与缺血性卒中后认知障碍的关系。结果认知功能障碍组血清VILIP-1浓度[(669.69±103.84)pg/ml]明显高于认知功能正常组[(503.29±142.39)pg/ml]及正常对照组[(491.18±116.30)pg/ml],差异均有统计学意义(P<0.01)。多因素logistic回归分析结果显示,高血清VILIP-1浓度(OR=1.017,P<0.01)、糖尿病(OR=3.838,P<0.05)、年龄增高(OR=1.070,P<0.05)、低受教育年限(OR=0.838,P<0.05)是缺血性卒中后认知障碍的独立危险因素。结论血清VILIP-1有望作为预测缺血性卒中后认知障碍的血液学生物标志物。Objective To explore the relationship between the serum visinin-like protein-1（VILIP-1） level or other factors and cognitive impairment in patients with ischemic stroke（IS） and to provide the base for preventing and treating the cognitive impairment after IS. Methods From June 1 to December 31 of 2012, 124 in-patients with acute cerebral infarction served as cerebral infarction group, 96 healthy volunteers served as control group which was matched with cerebral infarction group on the basis of age and gender. The cerebral infarction group was divided into two sub-groups with Montreal Cognitive Assessment Scale score results： cognitive impairment sub-group（51 cases） and normal cognitive function sub-group（73 cases）. The data of medical history and lifestyle of all subjects were collected. The serum VILIP-1,blood fat, homocysteine, high-sensitivity C-reactive protein levels for all subjects were measured. The levels of serum VILIP-1 among different groups were compared. The relationship between the serum VILIP-1 level or other factors and cognitive impairment after IS was analyzed. Results The serum VILIP-1level [（669.69±103.84） pg/ml] of cognitive impairment sub-group was significantly higher than that [（503.29 ± 142.39） pg/ml] of normal cognitive function sub-group and that [（491.18±116.30） pg/ml] of the normal control group（P〈0.01）. Multivariate logistic regression analysis showed that high serum VILIP-1 level（OR=1.017, P〈0.01）, diabetes（OR=3.838, P〈0.05）, the age（OR=1.070, P〈0.05） and lower education level（OR =0.838, P 〈0.05） were independent risk factors for cognitive impairment after ischemic stroke. Conclusion Serum VILIP-1 may be hetatologic biomaker to predict cognitive impairment in patients with IS.

关 键 词：缺血性卒中 认知障碍 视锥蛋白样蛋白-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]