急性脑梗死患者血清超敏C反应蛋白、纤维蛋白原和尿酸与颈动脉粥样硬化的关系  

Relationship of high sensitivity C-reactive protein,fibrinogen,uric acid and carotid artery arteriosclerosis in patients with acute cerebral infarction

作　　者：方志荣[1] 房林燕[1] 段冬云 张岗 

机构地区：[1]浙江舟山解放军第413医院内二科,舟山市316000 [2]浙江省宁波市江东区舟山警备区宁波第一干休所,宁波市315040

出　　处：《内科》2014年第5期523-525,共3页Internal Medicine

摘　　要：目的探讨超敏C反应蛋白(hs-CRP)、纤维蛋白原(Fbg)、尿酸(UA)水平与颈动脉粥样硬化的相关性。方法选择2010年1月至2013年12月在解放军413医院住院治疗的急性脑梗死患者120例作为实验组,选取同期健康体检者30例为对照组,分别测定两组观察对象血hs-CRP、Fbg、UA含量,采用颈动脉超声检查测定IMT,对所得数据进行统计分析。结果实验组患者血hs-CRP、Fbg、UA水平及IMT厚度均显著高于对照组(P<0.05);实验组患者随着IMT厚度增加,hs-CRP、Fbg、UA水平逐步升高(P<0.01)。结论血Hs-CRP、Fbg、UA水平的高低在脑梗死患者颈动脉粥样硬化发生发展中可能起重要的作用。Objective To explore relationship of high sensitivity C-reactive protein,fibrinogen,uric acid and carotid artery arteriosclerosis in patients with acute cerebral infarction. Methods 120 patients with acute cerebral infarction admitted from january2010 to december 2013 were as experimental group,meanwhile,30 healthy subjects who received medical check-up at the same period in our hospital were selected as the control group,the levels of serum Hs-CRP,Fbg,UA were measured,carotid intimalmedial thickness（ IMT） were measured by carotid artery ultrasound,the above indexes of two groups were compared. Results The levels of serum Hs-CRP,Fbg,UA and IMT thickness in the experimental group were significantly higher than those in the control group（ P〈0. 05）,in the experimental group,the levels of serum Hs-CRP,Fbg and UA were gradually increasing with the thickness of IMT increased（ P〈0. 01）. Conclusions The levels of serum Hs-CRP,Fbg and UA play a very important role in the occurrence and development of carotid atherosclerosis in patients with cerebral infarction.

关 键 词：急性脑梗死 颈动脉内-中膜厚度 超敏C反应蛋白 纤维蛋白原 尿酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]