离子导入对阿魏酸透皮吸收的促进作用  

Improvement effect of iontophoresis on transdermal permeation of ferulic acid

作　　者：杜丽娜[1] 刘笑[1,2] 贾俊伟[1,2] 韩光[2] 金义光[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所药物化学研究室,北京100850 [2]河南大学药学院,开封475004

出　　处：《国际药学研究杂志》2014年第5期595-598,共4页Journal of International Pharmaceutical Research

基　　金：国家"重大新药创制"科技重大专项综合性新药研究开发技术大平台资助项目(2012ZX09301003-001)

摘　　要：目的考查离子导入对阿魏酸透皮吸收的影响。方法采用小鼠腹部皮肤,以阿魏酸溶液为供体溶液,采用改良Franz扩散池,用紫外分光光度法测定受体池中药物含量,考察10 h内是否施加离子导入对阿魏酸透皮吸收的影响。结果离子导入明显促进体外模型中阿魏酸的皮肤透过量。结论离子导入能促进阿魏酸的透皮吸收,为中药其他有机酸成分的透皮吸收提供了实验依据。Objective To evaluate the improvement of iontophoresis on the transdermal permeation of ferulic acid. Methods The abdominal skin of mice was inserted in the modified Franz diffusion cell. Ferulic acid solution was the donor. The content of drug in the acceptor was quantified using the ultraviolet spectrophotometry. The influence of iontophoresis on permeation of ferulic acid was investigated within 10 hours. Results The transdermal amount of ferulic acid was significantly improved by iontophoresis in vitro.Conclusion Iontophoresis significantly improved ferulic acid permeation across skin. It could be a successful method to promote the skin permeation of other organic acids in traditional Chinese medicines.

关 键 词：离子导入 透皮 阿魏酸 累积透过量 

分 类 号：R285[医药卫生—中药学]