基因多态性与脑卒中相关性研究进展  

Research progress of the correlation between gene polymorphism and stroke

作　　者：蔡高宇[1] 卢钟娇[1] 傅毅[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科,200025

出　　处：《中国现代神经疾病杂志》2015年第2期92-97,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：上海市科研计划项目(项目编号:12ZR1418600)~~

摘　　要：脑卒中是当今社会严重威胁人类健康的常见病,其发病机制复杂、影响因素广泛。近年来,随着分子遗传学的发展,利用分子生物学技术对基因与脑卒中相关性进行病例对照研究,许多单核苷酸多态性被发现与脑卒中的发病密切相关。为了更好地揭示基因多态性与脑卒中的关联性,本文对近一年来国内外相关研究进行综述,以期更详尽地了解脑卒中致病基因的研究进展。Stroke is a common disease which has serious impact on human health in modern society. It has complex pathogenesis and wide- ranging influencing factors. Accompanied with the development of molecular genetics, a number of single nucleotide polymorphisms （SNPs） have been found to be closely related to the incidence of stroke in case-control studies on the correlation between genes and stroke by using molecular biology technologies. In order to have a better understanding on the correlation between gene polymorphism and stroke, this summary presents a review of literatures reported at home and abroad over the past year on the genetics of stroke.

关 键 词：卒中 基因 多态现象 遗传 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]