细菌及其代谢产物在神经系统疾病作用的研究进展  

Research progress of role of bacteria and their metabolites in neurological diseases

作　　者：冯新为[1] 张革[1] 

机构地区：[1]中山大学药学院微生物与生化药学实验室,广州510275

出　　处：《中国现代神经疾病杂志》2015年第2期165-168,共4页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(项目编号:81372573)~~

摘　　要：对分枝杆菌属细菌及其代谢产物参与神经胶质细胞重编程和神经保护过程进行阐述,并分析其中可能涉及的信号转导通路;系统介绍包括牙周病相关细菌、肠道菌群在内的消化道细菌及其代谢产物与阿尔茨海默病、多发性硬化、自闭症等中枢神经系统疾病发生与发展的关系。Mycobacteria and their metabolites which participate in the reprogramming of neurogliocytes and neuroprotection were summarized in this article, and the probable signaling pathways were also analyzed. The bacteria from digestive tract including periodontal and intestines involving in central nervous system diseases, such was Alzhermer＇s disease （AD）, multiple sclerosis （MS）, autism and so on, was introduced as well.

关 键 词：神经系统疾病 分枝杆菌属 细菌 肠 综述 

分 类 号：R741[医药卫生—神经病学与精神病学]