Bio-cluster nano-bomb for cancer drug delivery:efficacious fire at the target  

生物集束纳米炸弹消灭癌细胞:正中靶心(英文)

作　　者：Chun Wang 

机构地区：[1]Department of Biomedical Engineering,University of Minnesota

出　　处：《Science Bulletin》2015年第3期403-404,I0002,共3页科学通报（英文版）

摘　　要：Along with molecular targeted drugs and antibody-drug conjugates （ADC）, cancer nanomedicine has now been considered as one of the troika for advanced cancer treatment by delivering anticancer drugs to the tumor site with reduced side effects and enhanced therapeutic efficacy . As researchers learn more about cancer drug delivery process and tumor microenvironment , it is now recognized that nanomedicine must go through a CAPIR cascade of five steps, i.e., long circulation in the blood, high accumulation in the tumor through the leaky tumor-feeding vasculature, deep penetration into the tumor tissue, tumor cell internalization, and finally intracellular drug release. The inability of current nanomedicines to accomplish the whole CAPIR cascade accounts for their disappointing performance in clinical trials -they either fail to or only marginally improve the overall survival of human patients.与分子的指向的药和抗体药一起结合(模数转换器) ，癌症 nanomedicine 现在被与减少的副作用把 anticancer 药送到肿瘤地点为先进癌症治疗看作了三头马车之一并且提高了治疗学的功效[1 ] 。当研究人员们进一步了解癌症药交货过程和肿瘤微型环境[ 2 ]， nanomedicine 必须通过五步的 CAPIR 串联，这现在被认出，即，在血的长循环，在通过漏的喂肿瘤的 vasculature 的肿瘤的高累积，深穿入进肿瘤织物，肿瘤房间成为主观，和最后细胞内部的药版本。当前的 nanomedicines 的无能在临床的试用说明完成整个 CAPIR 串联他们的令人失望的性能[3 ] 他们也失败到或仅仅在边际地改进人的病人的全面幸存。图 ?

关 键 词：药物输送 纳米炸弹 抗癌药物 产业集群 肿瘤组织 对准 火力 生物 

分 类 号：R73-3[医药卫生—肿瘤]