结构性趋化因子及其受体与肿瘤  

The role of homeostatic chemokines and their receptors in cancer

作　　者：刘见荣[1] 可飞 侯风刚[1] 

机构地区：[1]上海中医药大学附属市中医医院肿瘤科,200071 [2]东南大学医学院病理与病理生理学系,南京210009

出　　处：《免疫学杂志》2015年第2期165-170,共6页Immunological Journal

基　　金：国家自然基金(81173221);上海市教委创新项目(12YZ057)

摘　　要：趋化因子方面的研究越来越多,但是对结构性趋化因子的系统性研究尚不多见。结构性趋化因子及其受体对于肿瘤的发生发展起着重要的作用,特别是在指导肿瘤转移方面。本文主要对结构性趋化因子及其受体,如CXCR4和CCR7在诱导淋巴细胞转移、器官的形成以及免疫耐受等方面的作用,重点对如何诱导转移及调控机制,以及在临床上抗癌治疗的指导意义方面进行以下阐述。Although researches on chemokines are increasing,systematic study on the homeostatic chemokines is few. The homeostatic chemokines and its receptors play vital roles in development process of many different types of cancers,such as leukocyte infiltrate,tumor cell growth,survival and invasion,especially in guiding tumor metastasis. In this paper,we focus on the functions and the mechanisms of homeostatic chemokines and its receptors in the metastasis. In addition,its importance in guiding clinical cancer therapy is also reviewed.

关 键 词：结构性趋化因子 结构性趋化因子受体 转移 CXCR4 CCR7 

分 类 号：R730.2[医药卫生—肿瘤]