Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-nave patients with schizophrenia  

作　　者：Ming-Li Li Bo Xiang Yin-Fei Li Xun Hu Qiang Wang Wan-Jun Guo Wei Lei Chao-Hua Huang Lian-Sheng Zhao Na Li Hong-Yan Ren Hui-Yao Wang Xiao-Hong Ma Wei Deng Tao Li 

机构地区：[1]The Mental Health Center and the Psychiatric Laboratory,West China Hospital,Sichuan University [2]State Key Laboratory of Biotherapy,West China Hospital,Sichuan University [3]Huaxi Biobank,West China Hospital,Sichuan University

出　　处：《Neuroscience Bulletin》2015年第1期31-42,共12页神经科学通报（英文版）

基　　金：supported by the National Nature Science Foundation of China (81130024,30530300,and 30125014);the National Key Technology R&D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan (2012BAI01B06);the Ph.D. Program Foundation of the Ministry of Education of China (20110181110014);the National Basic Research Development Program(973 Program) of China (2007CB512301)

摘　　要：The catechol-O-methyltransferase（COMT） gene is a schizophrenia susceptibility gene. A common functional polymorphism of this gene,Val158/158 Met,has been proposed to influence gray matter volume（GMV）. However,the effects of this polymorphism on cortical thickness/surface area in schizophrenic patients are less clear. In this study,we explored the relationship between the Val158 Met polymorphism of the COMT gene and the GMV/ cortical thickness/cortical surface area in 150 firstepisode treatment-nave patients with schizophrenia and 100 healthy controls. Main effects of diagnosis were found for GMV in the cerebellum and the visual,medial temporal,parietal,and middle frontal cortex. Patients with schizophrenia showed reduced GMVs in these regions. And main effects of genotype were detected for GMV in the left superior frontal gyrus. Moreover,a diagnosis × genotype interaction was found for the GMV of the left precuneus,and the effect of the COMT gene on GMV was due mainly to cortical thickness rather than cortical surface area. In addition,a pattern ofincreased GMV in the precuneus with increasing Met dose found in healthy controls was lost in patients with schizophrenia. These findings suggest that the COMTMet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia,and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area.The catechol-O-methyltransferase（COMT） gene is a schizophrenia susceptibility gene. A common functional polymorphism of this gene,Val158/158 Met,has been proposed to influence gray matter volume（GMV）. However,the effects of this polymorphism on cortical thickness/surface area in schizophrenic patients are less clear. In this study,we explored the relationship between the Val158 Met polymorphism of the COMT gene and the GMV/ cortical thickness/cortical surface area in 150 firstepisode treatment-nave patients with schizophrenia and 100 healthy controls. Main effects of diagnosis were found for GMV in the cerebellum and the visual,medial temporal,parietal,and middle frontal cortex. Patients with schizophrenia showed reduced GMVs in these regions. And main effects of genotype were detected for GMV in the left superior frontal gyrus. Moreover,a diagnosis × genotype interaction was found for the GMV of the left precuneus,and the effect of the COMT gene on GMV was due mainly to cortical thickness rather than cortical surface area. In addition,a pattern ofincreased GMV in the precuneus with increasing Met dose found in healthy controls was lost in patients with schizophrenia. These findings suggest that the COMTMet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia,and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area.

关 键 词：schizophrenia COMT gray matter imaging genetics 

分 类 号：R749.3[医药卫生—神经病学与精神病学]