Genetic studies of schizophrenia:an update  

作　　者：Jingchun Chen Fei Cao Lanfen Liu Lina Wang Xiangning Chen 

机构地区：[1]Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University [2]Department of Neurology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology [3]Department of Psychiatry,Shandong Mental Health Center

出　　处：《Neuroscience Bulletin》2015年第1期87-98,共12页神经科学通报（英文版）

基　　金：supported by the National Institutes of Health,USA (MH101054)

摘　　要：Schizophrenia（SCZ） is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identifi ed. These variants include risk loci identifi ed by genome-wide association studies,rare copy-number variants identifi ed by comparative genomic analyses,and de novo mutations identified by high-throughput DNA sequencing. Collectively,they contribute to the heterogeneity of the disease. In this review,we update recent discoveries in the fi eld of SCZ genetics,and outline the perspectives of future directions.Schizophrenia（SCZ） is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identifi ed. These variants include risk loci identifi ed by genome-wide association studies,rare copy-number variants identifi ed by comparative genomic analyses,and de novo mutations identified by high-throughput DNA sequencing. Collectively,they contribute to the heterogeneity of the disease. In this review,we update recent discoveries in the fi eld of SCZ genetics,and outline the perspectives of future directions.

关 键 词：schizophrenia genome-wide association study copy-number variant de novo mutation sequencing genetics 

分 类 号：R749.3[医药卫生—神经病学与精神病学]