干细胞治疗溃疡性结肠炎的研究进展  

Advances in stem cell treatment of ulcerative colitis

作　　者：徐萌[1] 范恒[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,湖北省武汉市430022

出　　处：《世界华人消化杂志》2015年第2期214-220,共7页World Chinese Journal of Digestology

摘　　要：干细胞(stem cells)不仅具有多向分化潜能和自我复制的能力,还具有免疫调节和促进血管增生的功能.炎症性肠病(inflammatory bowel disease,IBD)是一种病因和发病机制尚不明确的慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD).目前普遍认为UC的发病机制与免疫紊乱和黏膜血管的病变有关.本文就干细胞对UC的免疫调节和促进受损血管生成两方面的作用作一论述.Stem cells have the characteristics of multipotent differentiation and self-renewal and can modulate the immune system and promote angiogenesis.The etiology and pathogenesis of inflammatory bowel disease（IBD）, which includes ulcerative colitis（UC） and Crohn＇s disease（CD）, are still not clear. It is currently widely recognized that the pathogenesis of UC is related with immune disorders and vascular lesions of the colonic mucosa. This article reviews the effect of stem cells on immune regulation and angiogenesis in UC.

关 键 词：结肠炎 溃疡性 干细胞 免疫 血管 治疗 

分 类 号：R574.62[医药卫生—消化系统]